VOLTAIRE-AF Trial Opens: Real-World Evaluation of Volta AF-Xplorer II AI-Guided Mapping in AF Ablation — Key Details for Electrophysiologists
247 Health News Editorial
·6 July 2026
·4 min read
·clinical-trialsThe VOLTAIRE-AF registry (NCT07621055) is now recruiting 150 patients across French electrophysiology centres to evaluate the real-world safety and performance of Volta Medical's AF-Xplorer II AI mapping software during catheter ablation using next-generation mapping and pulsed-field ablation technologies. With 24-month follow-up and freedom-from-recurrence as a primary endpoint, this post-market study will generate the first systematic real-world evidence on AI-assisted substrate identification integrated with contemporary ablation platforms.
Originally reported by ClinicalTrials.gov
References
- 1.Volta Medical. (2025). Real-world experience of Volta Medical AI-software during AF ablation using next-generation mapping and ablation technologies (VOLTAIRE-AF) [Clinical trial registry entry]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07621055
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- 4.Lippi, G., Sanchis-Gomar, F., & Cervellin, G. (2021). Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. International Journal of Stroke, 16(2), 217–221. https://doi.org/10.1177/1747493019897870
- 5.Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström-Lundqvist, C., Boriani, G., Castella, M., Dan, G. A., Dilaveris, P. E., Fauchier, L., Filippatos, G., Kalman, J. M., La Meir, M., Lane, D. A., Lebeau, J. P., Lettino, M., Lip, G. Y. H., Pinto, F. J., … ESC Scientific Document Group. (2021). 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal, 42(5), 373–498. https://doi.org/10.1093/eurheartj/ehaa612
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247 Health News Editorial
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