TRUE-HF2 Trial Opens: Can Apple Watch Biometrics Predict Heart Failure Exacerbations and CPET Parameters? — What Clinicians Need to Know
247 Health News Editorial
·23 July 2026
·4 min read
·clinical-trialsThe TRUE-HF2 observational study, sponsored by the University Health Network in Toronto, is recruiting 360 heart failure patients to determine whether Apple Watch biometric data — combined with biomarkers and cardiac testing — can predict CPET parameters and anticipate HF exacerbations. The trial represents a landmark step toward integrating consumer wearables into evidence-based heart failure prognostication, with implications for remote monitoring and early intervention strategies globally.
Originally reported by ClinicalTrials.gov
References
- 1.University Health Network. (2025). Ted Rogers Understanding of Exacerbations in Heart Failure 2 (TRUE-HF2): Observational Study (NCT07447908). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07447908
- 2.Stehlik, J., Schmalfuss, C., Bozkurt, B., Nativi-Nicolau, J., Wohlfahrt, P., Wegerich, S., Potter, B., Svenson, L., Deswal, A., Bhatt, D. L., & Fang, J. C. (2020). Continuous wearable monitoring analytics predict hospitalization in heart failure patients. JACC: Heart Failure, 8(10), 830–840. https://doi.org/10.1016/j.jchf.2019.08.001
- 3.Guazzi, M., Arena, R., Halle, M., Piepoli, M. F., Myers, J., & Lavie, C. J. (2016). 2016 focused update: Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation, 133(24), e694–e711. https://doi.org/10.1161/CIR.0000000000000406
- 4.Savarese, G., Becher, P. M., Lund, L. H., Seferovic, P., Rosano, G. M. C., & Coats, A. J. S. (2023). Global burden of heart failure: A comprehensive and updated review of epidemiology. Cardiovascular Research, 118(17), 3272–3287. https://doi.org/10.1093/cvr/cvac013
- 5.McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., … ESC Scientific Document Group. (2021). 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, 42(36), 3599–3726. https://doi.org/10.1093/eurheartj/ehab368
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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