Health Technology/clinical-trials

Three-Arm RCT Opens: Digital Mindfulness-Based Therapy vs Pharmacotherapy vs Combined Treatment in OCD — Neurophysiological Mechanisms Under the Microscope

247 Health News Editorial

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3 Aug 2026

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4 min read

·clinical-trials

A new three-arm randomised controlled trial from Central South University is set to evaluate digital mindfulness-based therapy against routine pharmacological treatment — and their combination — in 150 individuals with OCD. Uniquely, the trial incorporates EEG and heart rate variability assessments to map the neurophysiological mechanisms driving treatment response, with follow-up extending to six months.

Originally reported by ClinicalTrials.gov

References

  1. 1.Central South University. (2025). Effects and neurophysiological mechanisms of digital mindfulness-based therapy for obsessive-compulsive disorder (NCT07701616). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07701616
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  3. 3.Fineberg, N. A., Van Ameringen, M., Drummond, L., Hollander, E., Stein, D. J., Geller, D., Walitza, S., Pallanti, S., Pellegrini, L., Zohar, J., Rodriguez, C. I., Menchon, J. M., Morgado, P., Mpavaenda, D., Fontenelle, L. F., Feusner, J. D., Grassi, G., Lochner, C., Veltman, D. J., & Chamberlain, S. R. (2020). How to manage obsessive-compulsive disorder (OCD) under COVID-19: A clinician's guide from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) and the Obsessive-Compulsive and Related Disorders Research Network (OCRN) of the European College of Neuropsychopharmacology. Comprehensive Psychiatry, 100, 152174. https://doi.org/10.1016/j.comppsych.2020.152174
  4. 4.Stein, D. J., Costa, D. L. C., Lochner, C., Miguel, E. C., Reddy, Y. C. J., Shavitt, R. G., van den Heuvel, O. A., & Simpson, H. B. (2019). Obsessive–compulsive disorder. Nature Reviews Disease Primers, 5(1), 52. https://doi.org/10.1038/s41572-019-0102-3
  5. 5.Strauss, C., Lea, L., Hayward, M., Forrester, E., Leeuwerik, T., Jones, A.-M., & Rosten, C. (2021). Mindfulness-based exposure and response prevention for obsessive compulsive disorder: Findings from a pilot randomised controlled trial. Journal of Anxiety Disorders, 82, 102447. https://doi.org/10.1016/j.janxdis.2021.102447
  6. 6.Lim, M. H., Rodebaugh, T. L., Zyphur, M. J., & Gleeson, J. F. M. (2022). Loneliness over time: The crucial role of social anxiety. Journal of Abnormal Psychology, 131(1), 37–47. https://doi.org/10.1037/abn0000747
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247 Health News Editorial

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