THINK-SHARP Trial Opens: AI-Powered Brain Health Coaching vs Standard Care in Dementia Prevention — What Clinicians Need to Know
247 Health News Editorial
·14 June 2026
·4 min read
·clinical-trialsThe THINK-SHARP trial evaluates an AI-powered WhatsApp-based brain health coaching intervention in 350 Singapore adults aged 40+. The study tests whether personalised lifestyle recommendations can improve Brain Care Scores and prevent cognitive decline.
Originally reported by ClinicalTrials.gov
References
- 1.Alexandra Hospital. (2024). Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention (THINK-SHARP). ClinicalTrials.gov. NCT07612800. https://clinicaltrials.gov/study/NCT07612800
- 2.Anstey, K. J., Ee, N., Eramudugolla, R., Jagger, C., & Peters, R. (2020). A systematic review of meta-analyses that evaluate risk factors for dementia to evaluate the quantity, quality, and global representativeness of evidence. Journal of Alzheimer's Disease, 70(S1), S165-S186. https://doi.org/10.3233/JAD-200181
- 3.Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., ... & Silverberg, N. (2018). NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimer's & Dementia, 14(4), 535-562. https://doi.org/10.1016/j.jalz.2018.02.018
- 4.Linardon, J., Cuijpers, P., Carlbring, P., Messer, M., & Fuller‐Tyszkiewicz, M. (2019). The efficacy of app‐supported smartphone interventions for mental health problems: a meta‐analysis of randomized controlled trials. World Psychiatry, 18(3), 325-336. https://doi.org/10.1002/wps.20673
- 5.Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., ... & Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, 396(10248), 413-446. https://doi.org/10.1016/S0140-6736(20)30367-6
- 6.Mukadam, N., Sommerlad, A., Huntley, J., & Livingston, G. (2019). Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data. The Lancet Global Health, 7(5), e596-e603. https://doi.org/10.1016/S2214-109X(19)30074-9
- 7.Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., ... & Kivipelto, M. (2015). A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. The Lancet, 385(9984), 2255-2263. https://doi.org/10.1016/S0140-6736(15)60461-5
- 8.Sano, M., Egelko, S., Donohue, M., Ferris, S., Galasko, D., Galvin, J. E., ... & Sabbagh, M. (2023). The Brain Care Score: a simple tool to assess lifestyle factors associated with brain health. Frontiers in Neurology, 14, 1215489. https://doi.org/10.3389/fneur.2023.1215489
- 9.Wimo, A., Seeher, K., Cataldi, R., Cyhlarova, E., Dielemann, J. L., Frisell, O., ... & Nichols, E. (2023). The worldwide costs of dementia in 2019. Alzheimer's & Dementia, 19(7), 2865-2873. https://doi.org/10.1002/alz.12901
- 10.World Health Organization. (2023). Dementia Fact Sheet. WHO Media Centre. https://www.who.int/news-room/fact-sheets/detail/dementia
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247 Health News Editorial
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