Telehealth vs In-Person Buprenorphine Referral After ED Presentation: Landmark RCT Targets the Critical Gap in OUD Continuity of Care
247 Health News Editorial
·16 July 2026
·4 min read
·clinical-trialsA landmark US comparative effectiveness trial is randomising 528 ED patients to telehealth versus in-person buprenorphine referral pathways following emergency department OUD presentations. With buprenorphine retention as the primary endpoint and follow-up extending to nine months, findings from NCT06961058 are poised to reshape post-ED OUD care models — with direct implications for Australian addiction medicine and telehealth policy.
Originally reported by ClinicalTrials.gov
References
- 1.University of California, Davis. (2025). In person vs telehealth opioid use disorder treatment after patients leave the emergency department (NCT06961058). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06961058
- 2.D'Onofrio, G., O'Connor, P. G., Pantalon, M. V., Chawarski, M. C., Busch, S. H., Owens, P. H., Bernstein, S. L., & Fiellin, D. A. (2015). Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: A randomized clinical trial. JAMA, 313(16), 1636–1644. https://doi.org/10.1001/jama.2015.3474
- 3.Mattick, R. P., Breen, C., Kimber, J., & Davoli, M. (2014). Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database of Systematic Reviews, 2014(2), CD002207. https://doi.org/10.1002/14651858.CD002207.pub4
- 4.Centers for Disease Control and Prevention. (2023). Drug overdose deaths in the United States, 2002–2022 (NCHS Data Brief No. 491). National Center for Health Statistics. https://www.cdc.gov/nchs/products/databriefs/db491.htm
- 5.Huskamp, H. A., Busch, A. B., Souza, J., Uscher-Pines, L., Rose, S., Wilcock, A., Landon, B. E., & Mehrotra, A. (2018). How is telemedicine being used in opioid and other substance use disorder treatment? Health Affairs, 37(12), 1940–1947. https://doi.org/10.1377/hlthaff.2018.05134
- 6.Tofighi, B., Sindhu, S. S., Chemi, C., Dickson, V. V., & Lee, J. D. (2019). Perspectives on the shifting patient-provider relationships and use of digital health technology amongst primary care patients receiving buprenorphine treatment. Substance Abuse Treatment, Prevention, and Policy, 14(1), 45. https://doi.org/10.1186/s13011-019-0240-9
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247 Health News Editorial
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