Suspended Trial Highlights Promise of Digital Prehabilitation for Cognitive Protection in Joint Replacement Surgery
247 Health News Editorial
·16 June 2026
·4 min read
·clinical-trialsA suspended University of Pennsylvania trial explored whether personalised prehabilitation delivered through wearable devices could protect cognitive function in older adults undergoing joint replacement surgery. The study targeted postoperative delirium, which affects up to 42% of hospitalised patients and significantly increases morbidity and mortality.
Originally reported by ClinicalTrials.gov
References
- 1.Australian Institute of Health and Welfare. (2023). Hip and knee replacements in Australia 2021-22 (AIHW-HSE-298). https://www.aihw.gov.au/reports/surgery/hip-and-knee-replacements-in-australia-2021-22
- 2.Gogenur, I., Ocak, U., Altunpinar, O., Middleton, B., Skene, D. J., & Rosenberg, J. (2007). Disturbances in melatonin, cortisol and core body temperature rhythms after major surgery. World Journal of Surgery, 31(7), 1449-1457. https://doi.org/10.1007/s00268-007-9144-2
- 3.Hshieh, T. T., Yue, J., Oh, E., Puelle, M., Dowal, S., Travison, T., & Inouye, S. K. (2015). Effectiveness of multicomponent nonpharmacological delirium interventions: A meta-analysis. JAMA Internal Medicine, 175(4), 512-520. https://doi.org/10.1001/jamainternmed.2014.7779
- 4.Inouye, S. K., Westendorp, R. G., & Saczynski, J. S. (2014). Delirium in elderly people. The Lancet, 383(9920), 911-922. https://doi.org/10.1016/S0140-6736(13)60688-1
- 5.Leslie, D. L., Marcantonio, E. R., Zhang, Y., Leo‐Summers, L., & Inouye, S. K. (2008). One‐year health care costs associated with delirium in the elderly population. Archives of Internal Medicine, 168(1), 27-32. https://doi.org/10.1001/archinte.168.1.27
- 6.Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695-699. https://doi.org/10.1111/j.1532-5415.2005.53221.x
- 7.University of Pennsylvania. (2024). A Personalized Medicine Prehabilitation Intervention Delivered Using Wearable Mobile Devices to Improve Cognitive Function in Elective Joint Replacement Surgery (NCT03601728). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT03601728
- 8.Witlox, J., Eurelings, L. S., de Jonghe, J. F., Kalisvaart, K. J., Eikelenboom, P., & van Gool, W. A. (2010). Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: A meta-analysis. JAMA, 304(4), 443-451. https://doi.org/10.1001/jama.2010.1013
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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