Stepped-Wedge Cluster RCT Launches: Digital ERAS Platform Targets Length of Stay After CABG — Lessons for Health Systems Globally

References

1. 1.University of São Paulo General Hospital. (2025). Randomized stepped-wedge cluster study to evaluate the impact of an ERAS-based technology platform on length of stay after coronary artery bypass grafting: Timely Project - REPLICCAR III (NCT06786819). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06786819
2. 2.Engelman, D. T., Ben Ali, W., Williams, J. B., Perrault, L. P., Reddy, V. S., Arora, R. C., Roselli, E. E., Khoynezhad, A., Gerdisch, M., Levy, J. H., Lobdell, K., Fletcher, N., Grocott, H. P., Grant, M. C., Crisafi, C., Brodt, J. L., & Engelman, R. M. (2019). Guidelines for perioperative care in cardiac surgery: Enhanced Recovery After Surgery Society recommendations. JAMA Surgery, 154(8), 755–766. https://doi.org/10.1001/jamasurg.2019.1153
3. 3.Fleming, I. O., Garratt, C., Guha, R., Desai, J., Chaubey, S., Wang, Y., Leonard, S., & Kunst, G. (2016). Aggregation of marginal gains in cardiac surgery: Feasibility of a perioperative care bundle for enhanced recovery in cardiac surgical patients. Journal of Cardiothoracic and Vascular Anesthesia, 30(3), 665–670. https://doi.org/10.1053/j.jvca.2016.02.030
4. 4.Hussey, M. A., & Hughes, J. P. (2007). Design and analysis of stepped wedge cluster randomized trials. Contemporary Clinical Trials, 28(2), 182–191. https://doi.org/10.1016/j.cct.2006.05.007
5. 5.Roth, G. A., Mensah, G. A., Johnson, C. O., Addolorato, G., Ammirati, E., Baddour, L. M., Barengo, N. C., Beaton, A. Z., Benjamin, E. J., Benziger, C. P., Bonny, A., Brauer, M., Brodmann, M., Cahill, T. J., Carapetis, J., Catapano, A. L., Chugh, S. S., Cooper, L. T., Coresh, J., … GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. (2020). Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study. Journal of the American College of Cardiology, 76(25), 2982–3021. https://doi.org/10.1016/j.jacc.2020.11.010
6. 6.Grant, M. C., Isada, T., Ruzankin, P., Whitman, G., Lawton, J. S., Dodd-o, J., Schulick, R., & Wick, E. (2020). Results from an enhanced recovery program for cardiac surgery. Journal of Thoracic and Cardiovascular Surgery, 159(4), 1393–1402. https://doi.org/10.1016/j.jtcvs.2019.03.117