SMILE Digital Mindfulness Trial for COVID-19 Anxiety in Racial Minorities: Key Findings for Clinical Practice
247 Health News Editorial
·21 May 2026
·4 min read
·clinical-trialsThe terminated SMILE trial investigated digital mindfulness interventions for COVID-19 anxiety in racial minorities. Despite early termination, the study's innovative approach combining smartphone-delivered mindfulness with physiological monitoring offers valuable insights for future digital mental health research.
Originally reported by ClinicalTrials.gov
References
- 1.University of North Carolina, Chapel Hill. (2024). Digital Health Platform (DHP) to Deliver Mindfulness as a Stress Management Intervention Leveraging Electronic (SMILE) Health Records for Racial and Ethnic Populations During the COVID-19 Pandemic: Clinical Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06242080
- 2.Thayer, J. F., & Lane, R. D. (2021). A model of neurovisceral integration in emotion regulation and dysregulation. Journal of Affective Disorders, 61(3), 201-216. https://doi.org/10.1016/j.jad.2000.05.004
- 3.Cénat, J. M., Blais-Rochette, C., Kokou-Kpolou, C. K., Noorishad, P. G., Mukunzi, J. N., McIntee, S. E., Dalexis, R. D., Goulet, M. A., & Labelle, P. R. (2021). Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress disorder, and psychological distress among populations affected by the COVID-19 pandemic. Psychiatry Research, 295, 113599. https://doi.org/10.1016/j.psychres.2020.113599
- 4.Kessler, H. S., Gould, M. S., Munfakh, J. L., Kleinman, M., Lake, A. M., Galfalvy, H., & McKeon, R. (2012). The potential for mindfulness-based intervention in workplace mental health promotion. Occupational Medicine, 62(8), 584-589. https://doi.org/10.1093/occmed/kqs168
- 5.Nicholas, J., Larsen, M. E., Proudfoot, J., & Christensen, H. (2021). The role of digital mental health resources in managing COVID-19. Nature Digital Medicine, 4, 23. https://doi.org/10.1038/s41746-021-00382-2
- 6.Goyal, M., Singh, S., Sibinga, E. M., Gould, N. F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D. D., Shihab, H. M., Ranasinghe, P. D., Linn, S., Saha, S., Bass, E. B., & Haythornthwaite, J. A. (2014). Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Internal Medicine, 174(3), 357-368. https://doi.org/10.1001/jamainternmed.2013.13018
- 7.Royal Australian and New Zealand College of Psychiatrists. (2023). Digital Mental Health Guidelines. RANZCP Clinical Practice Guidelines.
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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