Single-Case Digital Mental Health Trial: Low-Threshold Behavioural and Forgiveness Interventions Tested in Primary Care for Mild-to-Moderate Anxiety and Depression
247 Health News Editorial
·24 July 2026
·5 min read
·clinical-trialsUppsala University's completed exploratory trial tested two patient-chosen digital interventions — a behavioural activation programme and a forgiveness-based approach — for mild-to-moderate depression and anxiety in primary care. Using a single-case experimental design across 14 participants, the study aims to generate feasibility data critical for scaling low-threshold digital mental health support in primary care settings.
Originally reported by ClinicalTrials.gov
References
- 1.Uppsala University. (2025). Meeting psychiatric challenges in primary care via low-threshold digital mental health interventions (NCT07721870). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07721870
- 2.Linardon, J., Cuijpers, P., Carlbring, P., Messer, M., & Fuller-Tyszkiewicz, M. (2019). The efficacy of app-supported smartphone interventions for mental health problems: A meta-analysis of randomized controlled trials. World Psychiatry, 18(3), 325–336. https://doi.org/10.1002/wps.20673
- 3.Vlaeyen, J. W. S., Wicksell, R. K., Simons, L. E., Gentili, C., De, T. K., Tate, R. L., Vohra, S., & Punja, S. (2020). From Boulder to Stockholm in 70 years: Single case experimental designs in clinical research. The Psychological Record, 70(4), 659–670. https://doi.org/10.1007/s40732-020-00402-5
- 4.Cuijpers, P., Cristea, I. A., Karyotaki, E., Reijnders, M., & Huibers, M. J. H. (2016). How effective are cognitive behavior therapies for major depression and anxiety disorders? A meta-analytic update of the evidence. World Psychiatry, 15(3), 245–258. https://doi.org/10.1002/wps.20346
- 5.Pirkis, J., Ftanou, M., Williamson, M., Machlin, A., Spittal, M. J., Bassilios, B., & Harris, M. (2011). Australia's Better Access initiative: An evaluation. Australian & New Zealand Journal of Psychiatry, 45(9), 726–739. https://doi.org/10.3109/00048674.2011.594948
- 6.Andersson, G., Titov, N., Dear, B. F., Rozental, A., & Carlbring, P. (2019). Internet-delivered psychological treatments: From innovation to implementation. World Psychiatry, 18(1), 20–28. https://doi.org/10.1002/wps.20610
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service