Sanofi-Sponsored Validation Study Opens: Can EHR Diagnostic Codes Reliably Identify Chlamydial Infections? — Implications for a Future CT mRNA Vaccine Program
247 Health News Editorial
·30 July 2026
·4 min read
·clinical-trialsSanofi has opened a large-scale pharmacoepidemiologic study across 533,000 US patient records to validate whether ICD-10-CM diagnostic codes in the TriNetX EHR network can reliably identify chlamydial infections. The findings will directly underpin the data infrastructure for a future Chlamydia trachomatis mRNA vaccine program — a potentially landmark advance in STI prevention.
Originally reported by ClinicalTrials.gov
References
- 1.Sanofi. (2025). Validation of diagnostic codes for identifying chlamydial infections from TriNetX electronic health record data in the United States (NCT07094373). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07094373
- 2.Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021). Sexually transmitted infections treatment guidelines, 2021. MMWR Recommendations and Reports, 70(4), 1–187. https://doi.org/10.15585/mmwr.rr7004a1
- 3.Setoguchi, S., & Gerhard, T. (2021). Validity of diagnostic codes and laboratory values to identify patients with infectious diseases in claims and electronic health record data. Pharmacoepidemiology and Drug Safety, 30(3), 279–286. https://doi.org/10.1002/pds.5179
- 4.Centers for Disease Control and Prevention. (2023). Sexually transmitted infections surveillance, 2022. U.S. Department of Health and Human Services. https://www.cdc.gov/std/statistics/2022/default.htm
- 5.Haggerty, C. L., Gottlieb, S. L., Taylor, B. D., Low, N., Xu, F., & Ness, R. B. (2010). Risk of sequelae after Chlamydia trachomatis genital infection in women. Journal of Infectious Diseases, 201(Suppl 2), S134–S155. https://doi.org/10.1086/652395
- 6.Gottlieb, S. L., Deal, C. D., Giersing, B., Rees, H., Bolan, G., Johnston, C., Timms, P., Gray-Owen, S. D., Jerse, A. E., Cameron, C. E., Moorthy, V., & Brunham, R. C. (2016). The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps. Vaccine, 34(26), 2939–2947. https://doi.org/10.1016/j.vaccine.2016.06.039
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247 Health News Editorial
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