Health Technology/clinical-trials

Russian Population Study Develops Biological Age Calculator: RUSS-AGE Trial Seeks 3,500 Participants to Define Aging Biomarkers

247 Health News Editorial

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14 May 2026

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4 min read

·clinical-trials

The RUSS-AGE study aims to develop biological age calculators for the Russian population by analyzing comprehensive aging biomarkers in 3,500 participants. This research could transform clinical risk assessment by moving beyond chronological age to more accurate biological age measurements.

Originally reported by ClinicalTrials.gov

References

  1. 1.Pirogov Russian National Research Medical University. (2024). RUSS-AGE, Creating of a Biological Age Calculator and Study of Aging Phenotypes in the Russian Population. ClinicalTrials.gov. NCT07574359. https://clinicaltrials.gov/study/NCT07574359
  2. 2.López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023). Hallmarks of aging: An expanding universe. Cell, 186(2), 243-278. https://doi.org/10.1016/j.cell.2022.11.001
  3. 3.Jylhävä, J., Pedersen, N. L., & Hägg, S. (2017). Biological age predictors. EBioMedicine, 21, 29-36. https://doi.org/10.1016/j.ebiom.2017.03.046
  4. 4.Belsky, D. W., Caspi, A., Houts, R., Cohen, H. J., Corcoran, D. L., Danese, A., ... & Moffitt, T. E. (2015). Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences, 112(30), E4104-E4110. https://doi.org/10.1073/pnas.1506264112
  5. 5.Levine, M. E. (2013). Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age? The Journals of Gerontology Series A, 68(6), 667-674. https://doi.org/10.1093/gerona/gls233
  6. 6.Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics, 19(6), 371-384. https://doi.org/10.1038/s41576-018-0004-3
  7. 7.Ferrucci, L., Gonzalez-Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., ... & de Cabo, R. (2020). Measuring biological aging in humans: A quest. Aging Cell, 19(2), e13080. https://doi.org/10.1111/acel.13080
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