Resting-State fMRI and Machine Learning in Glioblastoma: Prospective Trial Seeks to Predict Survival and Guide Neurosurgical Planning
247 Health News Editorial
·16 July 2026
·5 min read
·clinical-trialsA prospective study at Washington University School of Medicine is enrolling 100 patients with suspected glioblastoma to test whether a support vector machine algorithm applied to preoperative resting-state fMRI can classify patients as short- or long-term survivors before surgery. The findings could transform neurosurgical neuronavigation and personalise treatment planning for one of oncology's most challenging diagnoses.
Originally reported by ClinicalTrials.gov
References
- 1.Washington University School of Medicine. (2023). Advancing neurosurgical neuronavigation using resting state MRI and machine learning - a prospective study (NCT05864976). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05864976
- 2.Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., Curschmann, J., Janzer, R. C., Ludwin, S. K., Gorlia, T., Allgeier, A., Lacombe, D., Cairncross, J. G., Eisenhauer, E., & Mirimanoff, R. O. (2005). Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New England Journal of Medicine, 352(10), 987–996. https://doi.org/10.1056/NEJMoa043330
- 3.Brown, T. J., Brennan, M. C., Li, M., Church, E. W., Brandmeir, N. J., Rakszawski, K. L., Patel, A. S., Rizk, E. B., Suki, D., Sawaya, R., & Glantz, M. (2016). Association of the extent of resection with survival in glioblastoma: A systematic review and meta-analysis. JAMA Oncology, 2(11), 1460–1469. https://doi.org/10.1001/jamaoncol.2016.1373
- 4.Leuthardt, E. C., Guzman, G., Bandt, S. K., Hacker, C. D., Vellimana, A. K., Limbrick, D. D., Milchenko, M., Shimony, J. S., & Snyder, A. Z. (2018). Integration of resting state fMRI into clinical practice — a large single institution experience. PLOS ONE, 13(6), e0198349. https://doi.org/10.1371/journal.pone.0198349
- 5.Duffau, H., & Mandonnet, E. (2013). The 'onco-functional balance' in surgery for diffuse low-grade glioma: Integrating the extent of resection with quality of life. Acta Neurochirurgica, 155(6), 951–957. https://doi.org/10.1007/s00701-012-1545-2
- 6.Aerts, H., Fries, P., & van den Heuvel, M. P. (2016). Neuronal dynamics underlying high- and low-frequency EEG oscillations contribute independently to the human BOLD signal. Neuron, 92(5), 983–999. https://doi.org/10.1016/j.neuron.2016.09.004
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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