Real-World Evidence Study Emulates KEYNOTE-042: Pembrolizumab vs Chemotherapy in Advanced NSCLC — What Clinicians Need to Know
247 Health News Editorial
·15 May 2026
·4 min read
·clinical-trialsNew study emulates landmark KEYNOTE-042 trial using real-world data from 770 patients with advanced NSCLC. Research validates pembrolizumab effectiveness in routine clinical practice, bridging gap between trial efficacy and real-world outcomes.
Originally reported by ClinicalTrials.gov
References
- 1.Brigham and Women's Hospital. (2024). Emulation of the KEYNOTE-042 (NCT02220894) Trial Using Specialty Oncology Electronic Health Records Databases. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07485179
- 2.Hernán, M. A., & Robins, J. M. (2020). Using big data to emulate a target trial when a randomized trial is not available. American Journal of Epidemiology, 189(6), 435-442. https://doi.org/10.1093/aje/kwaa084
- 3.Mok, T. S., Wu, Y. L., Kudaba, I., Kowalski, D. M., Cho, B. C., Turna, H. Z., Castro, G., Srimuninnimit, V., Laktionov, K. K., Bondarenko, I., Kubota, K., Lubiniecki, G. M., Zhang, J., Kush, D., & Lopes, G. (2019). Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial. The Lancet, 393(10183), 1819-1830. https://doi.org/10.1016/S0140-6736(18)32409-7
- 4.Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., & Peters, S. (2018). Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 29(Supplement 4), iv192-iv237. https://doi.org/10.1093/annonc/mdy275
- 5.Sherman, R. E., Anderson, S. A., Dal Pan, G. J., Gray, G. W., Gross, T., Hunter, N. L., LaVange, L., Marinac-Dabic, D., Marks, P. W., Robb, M. A., Shuren, J., Temple, R., Woodcock, J., Yue, L. Q., & Califf, R. M. (2016). Real-world evidence — what is it and what can it tell us? New England Journal of Medicine, 375(23), 2293-2297. https://doi.org/10.1056/NEJMsb1609216
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247 Health News Editorial
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