Prospective Validation Study Opens: AI-Powered Pediatric AKI Prediction Algorithm in ICU Settings — What Intensivists Need to Know
247 Health News Editorial
·10 Apr 2026
·4 min read
·clinical-trialsNew US study validates AI-powered algorithm to predict acute kidney injury in critically ill children within 72 hours of ICU admission. The 800-patient validation study aims to improve early detection and enable proactive interventions in pediatric intensive care.
Originally reported by ClinicalTrials.gov
References
- 1.Basu, R. K., Kaddourah, A., Terrell, T., Mottes, T., Wainwright, M. S., Goldstein, S. L., Akcan-Arikan, A., Menon, S., Basu, R. K., Kaddourah, A., Terrell, T., Mottes, T., Wainwright, M. S., Goldstein, S. L., & Akcan-Arikan, A. (2018). Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in critically ill children (AWARE): study protocol for a prospective observational study. BMC Nephrology, 19(1), 158. https://doi.org/10.1186/s12882-018-0955-x
- 2.Dziorny, A. C. (2024). Prospective Validation of AKI Prediction Algorithm. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06804200
- 3.Kaddourah, A., Basu, R. K., Bagshaw, S. M., Goldstein, S. L., & AWARE Investigators. (2017). Epidemiology of acute kidney injury in critically ill children and young adults. New England Journal of Medicine, 376(1), 11-20. https://doi.org/10.1056/NEJMoa1611391
- 4.Kellum, J. A., Lameire, N., Aspelin, P., Barsoum, R. S., Burdmann, E. A., Goldstein, S. L., Herzog, C. A., Joannidis, M., Kribben, A., Levey, A. S., MacLeod, A. M., Mehta, R. L., Murray, P. T., Naicker, S., Opal, S. M., Schaefer, F., Schetz, M., & Uchino, S. (2012). Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney International Supplements, 2(1), 1-138. https://doi.org/10.1038/kisup.2012.1
- 5.Sutherland, S. M., Byrnes, J. J., Kothari, M., Longhurst, C. A., Dutta, S., Garcia, P., & Goldstein, S. L. (2015). AKI in hospitalized children: comparing the pRIFLE, AKIN, and KDIGO definitions. Clinical Journal of the American Society of Nephrology, 10(4), 554-561. https://doi.org/10.2215/CJN.01900214
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