PRISM-GC Trial: Multimodal AI System to Predict Neoadjuvant Chemo-Immunotherapy Response in Locally Advanced Gastric Cancer
247 Health News Editorial
·22 May 2026
·3 min read
·clinical-trialsThe PRISM-GC study is developing an AI system to predict response to neoadjuvant chemo-immunotherapy in locally advanced gastric cancer. This 2,000-patient cohort study could transform treatment personalisation in gastric cancer care.
Originally reported by ClinicalTrials.gov
References
- 1.Al-Batran, S. E., Homann, N., Pauligk, C., Goetze, T. O., Meiler, J., Kasper, S., ... & Egger, M. (2019). Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 3 trial. The Lancet, 393(10184), 1948-1957. https://doi.org/10.1016/S0140-6736(18)32557-1
- 2.Joshi, S. S., & Badgwell, B. D. (2021). Current treatment and recent progress in gastric cancer. CA: A Cancer Journal for Clinicians, 71(3), 264-279. https://doi.org/10.3322/caac.21657
- 3.Sherman, R. E., Anderson, S. A., Dal Pan, G. J., Gray, G. W., Gross, T., Hunter, N. L., ... & Califf, R. M. (2016). Real-world evidence—what is it and what can it tell us? New England Journal of Medicine, 375(23), 2293-2297. https://doi.org/10.1056/NEJMsb1609216
- 4.Smyth, E. C., Nilsson, M., Grabsch, H. I., van Grieken, N. C., & Lordick, F. (2020). Gastric cancer. The Lancet, 396(10251), 635-648. https://doi.org/10.1016/S0140-6736(20)31288-5
- 5.Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249. https://doi.org/10.3322/caac.21660
- 6.Therapeutic Goods Administration. (2023). Software as Medical Device: Guidance for manufacturers. TGA Guidelines. https://www.tga.gov.au/resources/resource/guidance/software-medical-device-guidance-manufacturers
- 7.Zhao, Q. (2024). A Prospective, Multicenter, Real-World Cohort Study for the Development and Validation of a Multimodal Artificial Intelligence System to Predict Response to Neoadjuvant Chemo-Immunotherapy in Locally Advanced Gastric Cancer (The PRISM-GC Study) [Clinical trial registration NCT07401199]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07401199
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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