Health Technology/clinical-trials

PRISM-GC Trial: Multimodal AI System to Predict Neoadjuvant Chemo-Immunotherapy Response in Locally Advanced Gastric Cancer

247 Health News Editorial

·

22 May 2026

·

3 min read

·clinical-trials

The PRISM-GC study is developing an AI system to predict response to neoadjuvant chemo-immunotherapy in locally advanced gastric cancer. This 2,000-patient cohort study could transform treatment personalisation in gastric cancer care.

Originally reported by ClinicalTrials.gov

References

  1. 1.Al-Batran, S. E., Homann, N., Pauligk, C., Goetze, T. O., Meiler, J., Kasper, S., ... & Egger, M. (2019). Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 3 trial. The Lancet, 393(10184), 1948-1957. https://doi.org/10.1016/S0140-6736(18)32557-1
  2. 2.Joshi, S. S., & Badgwell, B. D. (2021). Current treatment and recent progress in gastric cancer. CA: A Cancer Journal for Clinicians, 71(3), 264-279. https://doi.org/10.3322/caac.21657
  3. 3.Sherman, R. E., Anderson, S. A., Dal Pan, G. J., Gray, G. W., Gross, T., Hunter, N. L., ... & Califf, R. M. (2016). Real-world evidence—what is it and what can it tell us? New England Journal of Medicine, 375(23), 2293-2297. https://doi.org/10.1056/NEJMsb1609216
  4. 4.Smyth, E. C., Nilsson, M., Grabsch, H. I., van Grieken, N. C., & Lordick, F. (2020). Gastric cancer. The Lancet, 396(10251), 635-648. https://doi.org/10.1016/S0140-6736(20)31288-5
  5. 5.Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249. https://doi.org/10.3322/caac.21660
  6. 6.Therapeutic Goods Administration. (2023). Software as Medical Device: Guidance for manufacturers. TGA Guidelines. https://www.tga.gov.au/resources/resource/guidance/software-medical-device-guidance-manufacturers
  7. 7.Zhao, Q. (2024). A Prospective, Multicenter, Real-World Cohort Study for the Development and Validation of a Multimodal Artificial Intelligence System to Predict Response to Neoadjuvant Chemo-Immunotherapy in Locally Advanced Gastric Cancer (The PRISM-GC Study) [Clinical trial registration NCT07401199]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07401199
Share:XLinkedIn
2

247 Health News Editorial

247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service