Health Technology/clinical-trials

PREDICT Trial Opens: Personalised Risk-Based Cervical Cancer Screening vs Standard Care — What Primary Care Clinicians Need to Know

247 Health News Editorial

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11 June 2026

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4 min read

·clinical-trials

The PREDICT trial evaluates personalised, risk-based cervical cancer screening follow-up using electronic health record reminders in primary care. This cluster-randomised study of 7,500 participants compares standard care with targeted IT interventions for higher-risk individuals.

Originally reported by ClinicalTrials.gov

References

  1. 1.Massachusetts General Hospital. (2024). Personalized Risk-based Follow-up of Cervical Cancer Screening in Practice (PREDICT), Randomized Control Trial. ClinicalTrials.gov. NCT06872346. https://clinicaltrials.gov/study/NCT06872346
  2. 2.Katki, H. A., Kinney, W. K., Fetterman, B., Lorey, T., Poitras, N. E., Cheung, L., Demuth, F., Schiffman, M., Wacholder, S., & Castle, P. E. (2011). Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice. Lancet Oncology, 12(7), 663-672. https://doi.org/10.1016/S1470-2045(11)70145-0
  3. 3.Sawaya, G. F., Kulasingam, S., Denberg, T. D., & Qaseem, A. (2015). Cervical cancer screening in average-risk women: best practice advice from the Clinical Guidelines Committee of the American College of Physicians. Annals of Internal Medicine, 162(12), 851-859. https://doi.org/10.7326/M14-2426
  4. 4.Spence, A. R., Goggin, P., & Franco, E. L. (2007). Process of care failures in invasive cervical cancer: systematic review and meta-analysis. Preventive Medicine, 45(2-3), 93-106. https://doi.org/10.1016/j.ypmed.2006.10.018
  5. 5.Cancer Council Australia. (2022). National Cervical Screening Program: Guidelines for the management of screen-detected abnormalities, screening in specific populations and investigation of symptoms. Cancer Council Australia. https://www.cancer.org.au/clinical-guidelines/cervical-cancer-screening
  6. 6.Baron, R. C., Melillo, S., Rimer, B. K., Coates, R. J., Kerner, J., Habarta, N., Chattopadhyay, S., Sabatino, S. A., Elder, R., & Leeks, K. J. (2010). Intervention to increase recommendation and delivery of screening for breast, cervical, and colorectal cancers by healthcare providers: systematic reviews of provider assessment and feedback and provider incentives. American Journal of Preventive Medicine, 38(1), 110-117. https://doi.org/10.1016/j.amepre.2009.10.016
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247 Health News Editorial

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