Pragmatic Trial Tests AI-Powered Sepsis and Deterioration Prediction Scores Across 150,000 Patients — Early Detection Strategy Under Investigation
247 Health News Editorial
·12 May 2026
·4 min read
·clinical-trialsA groundbreaking 150,000-patient pragmatic trial is testing two predictive scoring systems designed to identify sepsis and patient deterioration four hours before clinical recognition. The study could transform proactive patient monitoring in acute care settings.
Originally reported by ClinicalTrials.gov
References
- 1.University of Maryland, Baltimore. (2024). Sepsis Early Prediction System Score (SEPSys Score) and RESCUE Score Multi-Site, Two-Intervention, Cluster-Randomized, Factorial Stepped-Wedge Pragmatic Clinical Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06779617
- 2.Rhee, C., Dantes, R., Epstein, L., Murphy, D. J., Seymour, C. W., Iwashyna, T. J., Kadri, S. S., Angus, D. C., Danner, R. L., Fiore, A. E., Jernigan, J. A., Martin, G. S., Septimus, E., Warren, D. K., Karcz, A., Chan, C., Menchaca, J. T., Wang, R., Gruber, S., & Klompas, M. (2017). Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014. JAMA, 318(13), 1241-1249. https://doi.org/10.1001/jama.2017.13836
- 3.Hemming, K., Haines, T. P., Chilton, P. J., Girling, A. J., & Lilford, R. J. (2015). The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting. BMJ, 350, h391. https://doi.org/10.1136/bmj.h391
- 4.Ford, I., & Norrie, J. (2016). Pragmatic trials. New England Journal of Medicine, 375(5), 454-463. https://doi.org/10.1056/NEJMra1510059
- 5.Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J. D., Coopersmith, C. M., Hotchkiss, R. S., Levy, M. M., Marshall, J. C., Martin, G. S., Opal, S. M., Rubenfeld, G. D., van der Poll, T., Vincent, J. L., & Angus, D. C. (2016). The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 315(8), 801-810. https://doi.org/10.1001/jama.2016.0287
- 6.Seymour, C. W., Gesten, F., Prescott, H. C., Friedrich, M. E., Iwashyna, T. J., Phillips, G. S., Lemeshow, S., Osborn, T., Terry, K. M., & Levy, M. M. (2017). Time to treatment and mortality during mandated emergency care for sepsis. New England Journal of Medicine, 376(23), 2235-2244. https://doi.org/10.1056/NEJMoa1703058
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247 Health News Editorial
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