Pilot Trial Opens: Can Retinal Imaging Detect Transthyretin Amyloid Cardiomyopathy Non-Invasively? AstraZeneca Study Targets 500 Patients Across Four Countries
247 Health News Editorial
·26 July 2026
·4 min read
·clinical-trialsAstraZeneca has launched a multicenter pilot study investigating whether non-invasive retinal imaging can detect transthyretin amyloid cardiomyopathy (ATTR-CM) — a condition that remains critically underdiagnosed despite the availability of effective therapies. The 500-participant study across the US, Germany, Portugal, and Spain aims to assess the feasibility of an ocular imaging-based screening model that could transform the diagnostic pathway for this progressive cardiac condition.
Originally reported by ClinicalTrials.gov
References
- 1.AstraZeneca. (2025). A multicenter pilot study to investigate ocular involvement and the potential of ocular imaging for non-invasive screening for transthyretin amyloid cardiomyopathy (ATTR-CM) (NCT07690436). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07690436
- 2.Patel, P., Bhatt, N., Bhatt, A., et al. (2021). Ocular manifestations of systemic amyloidosis: A review. Survey of Ophthalmology, 66(5), 777–785. https://doi.org/10.1016/j.survophthal.2021.01.004
- 3.Gertz, M. A. (2020). Immunoglobulin light chain amyloidosis: 2020 update on diagnosis, prognosis, and treatment. American Journal of Hematology, 95(7), 848–860. https://doi.org/10.1002/ajh.25680
- 4.Damy, T., Costes, B., Hagège, A. A., et al. (2016). Prevalence and clinical phenotype of hereditary transthyretin amyloid cardiomyopathy in patients with increased left ventricular wall thickness. European Heart Journal, 37(23), 1826–1834. https://doi.org/10.1093/eurheartj/ehv583
- 5.Maurer, M. S., Schwartz, J. H., Gundapaneni, B., et al. (2018). Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. New England Journal of Medicine, 379(11), 1007–1016. https://doi.org/10.1056/NEJMoa1805689
- 6.Gillmore, J. D., Maurer, M. S., Falk, R. H., et al. (2016). Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation, 133(24), 2404–2412. https://doi.org/10.1161/CIRCULATIONAHA.116.021612
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247 Health News Editorial
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