Health Technology/clinical-trials

Pilot Trial Demonstrates Feasibility of Prolonged Nightly Fasting for Men on Androgen Deprivation Therapy — Implications for Metabolic Health

247 Health News Editorial

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14 May 2026

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4 min read

·clinical-trials

A completed pilot trial demonstrates the feasibility of prolonged nightly fasting with telehealth support for men on androgen deprivation therapy. The intervention showed good patient acceptance and engagement, providing foundation data for larger efficacy studies addressing ADT-related metabolic complications.

Originally reported by ClinicalTrials.gov

References

  1. 1.Grossmann, M., & Zajac, J. D. (2011). Management of side effects of androgen deprivation therapy. Endocrinology and Metabolism Clinics, 40(3), 655-671. https://doi.org/10.1016/j.ecl.2011.05.004
  2. 2.Keating, N. L., O'Malley, A. J., & Smith, M. R. (2006). Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. Journal of Clinical Oncology, 24(27), 4448-4456. https://doi.org/10.1200/JCO.2006.06.2497
  3. 3.Longo, V. D., & Mattson, M. P. (2014). Fasting: molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-192. https://doi.org/10.1016/j.cmet.2013.12.008
  4. 4.Nguyen, P. L., Alibhai, S. M., Basaria, S., D'Amico, A. V., Kantoff, P. W., Keating, N. L., ... & Smith, M. R. (2015). Adverse effects of androgen deprivation therapy and strategies to mitigate them. European Urology, 67(5), 825-836. https://doi.org/10.1016/j.eururo.2014.07.010
  5. 5.Pharmaceutical Benefits Scheme. (2024). PBS Schedule - Prostate Cancer Treatments. Australian Government Department of Health. https://www.pbs.gov.au/
  6. 6.Thomas Jefferson University. (2024). A Prolonged Nightly Fasting Plus Telehealth Coaching Intervention (PNF+) for Men on Androgen Deprivation Therapy for PCa: A Pilot Feasibility Randomized Controlled. ClinicalTrials.gov. NCT07462403. https://clinicaltrials.gov/study/NCT07462403
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