Health Technology/clinical-trials

Pilot Study Explores Physiological Monitoring During Ketamine-Assisted Therapy for PTSD — Novel Autonomic Signal Detection Protocol

247 Health News Editorial

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16 June 2026

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3 min read

·clinical-trials

Canadian researchers are pioneering continuous physiological monitoring during ketamine-assisted therapy for PTSD, using wearable biosensors to detect autonomic nervous system patterns. This pilot study could revolutionise personalised trauma treatment through objective biomarkers.

Originally reported by ClinicalTrials.gov

References

  1. 1.van der Wart, A. D. (2024). Intra-Sessional Autonomic Arc Detection Using Continuous HRV and EDA Monitoring in Adults Undergoing Ketamine-Assisted Therapy for PTSD: A Prospective Observational Signal Characterisation Pilot Study. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07614581
  2. 2.Garfinkel, S. N., Balsters, J. H., Seth, A. K., Daly, E., McAlonan, G., & Critchley, H. D. (2023). Digital biomarkers and the future of mental health care. Nature Medicine, 29(10), 2401-2402. https://doi.org/10.1038/s41591-023-02483-1
  3. 3.Krystal, J. H., Abdallah, C. G., Sanacora, G., Charney, D. S., & Duman, R. S. (2019). Ketamine: A paradigm shift for depression research and treatment. Neuron, 101(5), 774-778. https://doi.org/10.1016/j.neuron.2019.02.005
  4. 4.Feder, A., Costi, S., Rutter, S. B., Collins, A. B., Govindarajulu, U., Jha, M. K., Horn, S. R., Kautz, M., Corniquel, M., Collins, K. A., Bevilacqua, L., Glasgow, A. M., Brallier, J., Pietrzak, R. H., Murrough, J. W., & Charney, D. S. (2021). Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder. JAMA Psychiatry, 78(1), 68-73. https://doi.org/10.1001/jamapsychiatry.2021.0394
  5. 5.Koenen, K. C., Ratanatharathorn, A., Ng, L., McLaughlin, K. A., Bromet, E. J., Stein, D. J., Karam, E. G., Meron Ruscio, A., Benjet, C., Scott, K., Atwoli, L., Petukhova, M., Lim, C. C. W., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., Bunting, B., Ciutan, M., de Girolamo, G., ... Kessler, R. C. (2017). Posttraumatic stress disorder in the World Mental Health Surveys. Psychological Medicine, 47(13), 2260-2274. https://doi.org/10.1017/S0033291717000708
  6. 6.Sheynin, J., Duval, E. R., King, A. P., Angstadt, M., Phan, K. L., Simon, N. M., Rauch, S. A. M., & Liberzon, I. (2022). Associations between resting heart rate variability and PTSD symptoms. Psychophysiology, 59(8), e14072. https://doi.org/10.1111/psyp.14072
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247 Health News Editorial

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