Pilot Study Explores Physiological Monitoring During Ketamine-Assisted Therapy for PTSD — Novel Autonomic Signal Detection Protocol
247 Health News Editorial
·16 June 2026
·3 min read
·clinical-trialsCanadian researchers are pioneering continuous physiological monitoring during ketamine-assisted therapy for PTSD, using wearable biosensors to detect autonomic nervous system patterns. This pilot study could revolutionise personalised trauma treatment through objective biomarkers.
Originally reported by ClinicalTrials.gov
References
- 1.van der Wart, A. D. (2024). Intra-Sessional Autonomic Arc Detection Using Continuous HRV and EDA Monitoring in Adults Undergoing Ketamine-Assisted Therapy for PTSD: A Prospective Observational Signal Characterisation Pilot Study. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07614581
- 2.Garfinkel, S. N., Balsters, J. H., Seth, A. K., Daly, E., McAlonan, G., & Critchley, H. D. (2023). Digital biomarkers and the future of mental health care. Nature Medicine, 29(10), 2401-2402. https://doi.org/10.1038/s41591-023-02483-1
- 3.Krystal, J. H., Abdallah, C. G., Sanacora, G., Charney, D. S., & Duman, R. S. (2019). Ketamine: A paradigm shift for depression research and treatment. Neuron, 101(5), 774-778. https://doi.org/10.1016/j.neuron.2019.02.005
- 4.Feder, A., Costi, S., Rutter, S. B., Collins, A. B., Govindarajulu, U., Jha, M. K., Horn, S. R., Kautz, M., Corniquel, M., Collins, K. A., Bevilacqua, L., Glasgow, A. M., Brallier, J., Pietrzak, R. H., Murrough, J. W., & Charney, D. S. (2021). Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder. JAMA Psychiatry, 78(1), 68-73. https://doi.org/10.1001/jamapsychiatry.2021.0394
- 5.Koenen, K. C., Ratanatharathorn, A., Ng, L., McLaughlin, K. A., Bromet, E. J., Stein, D. J., Karam, E. G., Meron Ruscio, A., Benjet, C., Scott, K., Atwoli, L., Petukhova, M., Lim, C. C. W., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., Bunting, B., Ciutan, M., de Girolamo, G., ... Kessler, R. C. (2017). Posttraumatic stress disorder in the World Mental Health Surveys. Psychological Medicine, 47(13), 2260-2274. https://doi.org/10.1017/S0033291717000708
- 6.Sheynin, J., Duval, E. R., King, A. P., Angstadt, M., Phan, K. L., Simon, N. M., Rauch, S. A. M., & Liberzon, I. (2022). Associations between resting heart rate variability and PTSD symptoms. Psychophysiology, 59(8), e14072. https://doi.org/10.1111/psyp.14072
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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