Phase NA RCT Opens: mHealth-Based Home Cardiac Rehabilitation vs Routine Care in Mild-to-Moderate Coronary Stenosis — Can a Digital Platform Reverse Plaque Progression?
247 Health News Editorial
·7 July 2026
·4 min read
·clinical-trialsA new randomised controlled trial from the China National Center for Cardiovascular Diseases is investigating whether a mobile internet-based home cardiac rehabilitation program can reduce non-calcified coronary plaque volume in patients with mild-to-moderate stenosis. The 176-participant study uses coronary CT angiography as its primary endpoint at 12 months, with 36-month follow-up — potentially providing the first robust imaging evidence linking digital rehabilitation to plaque modification in early-stage CAD.
Originally reported by ClinicalTrials.gov
References
- 1.China National Center for Cardiovascular Diseases. (2025). Effect of mobile internet technology-based home cardiac rehabilitation on coronary artery plaque in patients with mild to moderate stenosis (NCT07660419). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07660419
- 2.Nicholls, S. J., Puri, R., Anderson, T., Ballantyne, C. M., Cho, L., Kastelein, J. J. P., Koenig, W., Somaratne, R., Kassahun, H., Yang, J., Wasserman, S. M., Scott, R., Ungi, I., Podolec, J., Ophuis, A. O., Cornel, J. H., Borgman, M., Brennan, D. M., & Nissen, S. E. (2016). Effect of evolocumab on progression of coronary disease in statin-treated patients: The GLAGOV randomized clinical trial. JAMA, 316(22), 2373–2384. https://doi.org/10.1001/jama.2016.16951
- 3.Anderson, L., Sharp, G. A., Norton, R. J., Dalal, H., Dean, S. G., Jolly, K., Cowie, A., Zawada, A., & Taylor, R. S. (2017). Home-based versus centre-based cardiac rehabilitation. Cochrane Database of Systematic Reviews, 6, CD007130. https://doi.org/10.1002/14651858.CD007130.pub4
- 4.Maurovich-Horvat, P., Ferencik, M., Voros, S., Merkely, B., & Hoffmann, U. (2014). Comprehensive plaque assessment by coronary CT angiography. Nature Reviews Cardiology, 11(7), 390–402. https://doi.org/10.1038/nrcardio.2014.60
- 5.Roth, G. A., Mensah, G. A., Johnson, C. O., Addolorato, G., Ammirati, E., Baddour, L. M., Barengo, N. C., Beaton, A. Z., Benjamin, E. J., Benziger, C. P., Bonny, A., Brauer, M., Brodmann, M., Cahill, T. J., Carapetis, J., Catapano, A. L., Chugh, S. S., Cooper, L. T., Coresh, J., … GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. (2020). Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study. Journal of the American College of Cardiology, 76(25), 2982–3021. https://doi.org/10.1016/j.jacc.2020.11.010
- 6.Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., Agewall, S., Dickstein, K., Edvardsen, T., Escaned, J., Gersh, B. J., Svitil, P., Gilard, M., Hasdai, D., Hatala, R., … ESC Scientific Document Group. (2020). 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal, 41(3), 407–477. https://doi.org/10.1093/eurheartj/ehz425
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service