Phase NA Feasibility Trial Opens: Home-Based 60Hz Intermittent Light Therapy vs Sham in Major Depressive Disorder — What Clinicians Need to Know
247 Health News Editorial
·16 July 2026
·5 min read
·clinical-trialsNYU Langone Health has opened recruitment for a randomised feasibility pilot study evaluating home-based 60Hz intermittent light therapy — delivered via a wearable headset — as an adjunctive treatment for adults with moderate-to-severe major depressive disorder. The trial will assess session adherence, safety, and preliminary symptom change across a three-week, fully remote protocol in 40 participants.
Originally reported by ClinicalTrials.gov
References
- 1.NYU Langone Health. (2025). A feasibility pilot study of home-based intermittent 60Hz light therapy for the treatment of depression (NCT07111390). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07111390
- 2.Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., Adaikkan, C., Canter, R. G., Rueda, R., Brown, E. N., Boyden, E. S., & Tsai, L. H. (2016). Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature, 540(7632), 230–235. https://doi.org/10.1038/nature20587
- 3.Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., McGrath, P. J., Rosenbaum, J. F., Sackeim, H. A., Kupfer, D. J., Luther, J., & Fava, M. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. American Journal of Psychiatry, 163(11), 1905–1917. https://doi.org/10.1176/ajp.2006.163.11.1905
- 4.Lam, R. W., Levitt, A. J., Levitan, R. D., Enns, M. W., Morehouse, R., Michalak, E. E., & Tam, E. M. (2006). The Can-SAD study: A randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder. American Journal of Psychiatry, 163(5), 805–812. https://doi.org/10.1176/ajp.2006.163.5.805
- 5.World Health Organization. (2023). Depressive disorder (depression): Fact sheet. https://www.who.int/news-room/fact-sheets/detail/depression
- 6.Perera, T., George, M. S., Grammer, G., Janicak, P. G., Pascual-Leone, A., & Wirecki, T. S. (2016). The Clinical TMS Society consensus review and treatment recommendations for TMS therapy for major depressive disorder. Brain Stimulation, 9(3), 336–346. https://doi.org/10.1016/j.brs.2016.03.010
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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