Phase IV Trial Terminated: Machine Learning-Guided Hydroxyurea Resistance Prediction in Polycythemia Vera — Clinical Implications for Haematologists
247 Health News Editorial
·8 Apr 2026
·4 min read
·clinical-trialsThe terminated HU-F-AIM trial attempted to validate machine learning predictions for hydroxyurea resistance in polycythemia vera patients. Despite early closure, this study highlighted important advances in precision medicine approaches for myeloproliferative neoplasms.
Originally reported by ClinicalTrials.gov
References
- 1.Barbui, T., Tefferi, A., Vannucchi, A. M., Passamonti, F., Silver, R. T., Hoffman, R., ... & Kiladjian, J. J. (2018). Philadelphia chromosome-negative classical myeloproliferative neoplasms: revised management recommendations from European LeukemiaNet. Leukemia, 32(5), 1057-1069. https://doi.org/10.1038/s41375-018-0077-1
- 2.Barosi, G., Mesa, R., Finazzi, G., Harrison, C., Kiladjian, J. J., Lengfelder, E., ... & Barbui, T. (2013). Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project. Blood, 121(23), 4778-4781. https://doi.org/10.1182/blood-2013-01-478891
- 3.ClinicalTrials.gov. (2024). HU-F-AIM - A Prospective, Interventional Study to Evaluate HU-resistance in Polycythemia Vera Patients Who Meet Predictive Parameters Identified in the Machine Learning Project PV-AIM. https://clinicaltrials.gov/study/NCT05853458
- 4.Khoury, J. D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J. F., ... & Zuo, Z. (2022). The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia, 36(7), 1703-1719. https://doi.org/10.1038/s41375-022-01613-1
- 5.Tefferi, A. (2021). Polycythemia vera: 2021 update on diagnosis, risk-stratification, and management. American Journal of Hematology, 96(4), 444-467. https://doi.org/10.1002/ajh.26063
- 6.Verstovsek, S., Vannucchi, A. M., Griesshammer, M., Masszi, T., Durrant, S., Passamonti, F., ... & Kiladjian, J. J. (2017). Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial. Haematologica, 102(12), 2056-2065. https://doi.org/10.3324/haematol.2016.153098
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247 Health News Editorial
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