Health Technology/clinical-trials

Phase IV Trial Probes Acamprosate's Neural Mechanisms in AUD via EEG Beta Power — Implications for Personalised Treatment

247 Health News Editorial

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21 July 2026

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4 min read

·clinical-trials

A Phase IV NIAAA-sponsored trial is using high-density EEG to map how acamprosate modulates cortical beta oscillations in patients with moderate to severe alcohol use disorder. The mechanistic study aims to identify neurophysiological biomarkers that could explain variable treatment response and guide more personalised prescribing of this TGA-registered pharmacotherapy.

Originally reported by ClinicalTrials.gov

References

  1. 1.National Institute on Alcohol Abuse and Alcoholism (NIAAA). (2024). Temporally-resolved electrophysiology of acamprosate treatment of alcohol use disorder (NCT06269627). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06269627
  2. 2.Maisel, N. C., Blodgett, J. C., Wilbourne, P. L., Humphreys, K., & Finney, J. W. (2013). Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: When are these medications most helpful? Addiction, 108(2), 275–293. https://doi.org/10.1111/j.1360-0443.2012.04054.x
  3. 3.Bates, M. E., Buckman, J. F., & Nguyen, T. T. (2013). A role for cognitive rehabilitation in increasing the effectiveness of treatment for alcohol use disorders. Neuropsychology Review, 23(1), 27–47. https://doi.org/10.1007/s11065-013-9228-3
  4. 4.Rangaswamy, M., & Porjesz, B. (2014). Understanding alcohol use disorders with neuroelectrophysiology. Handbook of Clinical Neurology, 125, 383–414. https://doi.org/10.1016/B978-0-444-62619-6.00019-X
  5. 5.GBD 2016 Alcohol Collaborators. (2018). Alcohol use and burden for 195 countries and territories, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet, 392(10152), 1015–1035. https://doi.org/10.1016/S0140-6736(18)31310-2
  6. 6.Krupitsky, E. M., Burakov, A. M., Romanova, T. N., Grinenko, N. I., Grinenko, A. Y., Fletcher, J., & Petrakis, I. L. (2007). Attenuation of cue-induced alcohol craving and autonomic reactivity by naltrexone in recently detoxified alcoholics. Addiction, 102(7), 1099–1107. https://doi.org/10.1111/j.1360-0443.2007.01840.x
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