Phase IV Trial Opens: QiLin AI System vs Standard Care for Anti-VEGF Treatment Decisions in Retinal Disease — What Ophthalmologists Need to Know
247 Health News Editorial
·31 May 2026
·3 min read
·clinical-trialsNew randomised trial evaluates QiLin AI system to assist ophthalmologists in anti-VEGF treatment decisions for retinal diseases. The study compares AI-assisted versus standard physician decision-making in 200 patients with AMD, DME, and RVO.
Originally reported by ClinicalTrials.gov
References
- 1.Shanghai General Hospital. (2024). An Artificial Intelligence System for Anti-VEGF Treatment Decisions in Retinal Diseases: A Randomized Controlled Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07328776
- 2.Schmidt-Erfurth, U., Chong, V., Loewenstein, A., Larsen, M., Souied, E., Schlingemann, R., Eldem, B., Monés, J., Richard, G., & Bandello, F. (2014). Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). British Journal of Ophthalmology, 98(9), 1144-1167. https://doi.org/10.1136/bjophthalmol-2013-304637
- 3.Holz, F. G., Tadayoni, R., Beatty, S., Berger, A., Cereda, M. G., Cortez, R., Hoyng, C. B., Hykin, P., Staurenghi, G., Heldner, S., Bogumil, T., Heah, T., Sivaprasad, S., & LUMINOUS Study Group. (2015). Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration. British Journal of Ophthalmology, 99(2), 220-226. https://doi.org/10.1136/bjophthalmol-2014-305327
- 4.Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., Kim, R. Y., & MARINA Study Group. (2006). Ranibizumab for neovascular age-related macular degeneration. New England Journal of Medicine, 355(14), 1419-1431. https://doi.org/10.1056/NEJMoa054481
- 5.Wells, J. A., Glassman, A. R., Ayala, A. R., Jampol, L. M., Aiello, L. P., Antoszyk, A. N., Arnold-Bush, B., Baker, C. W., Bressler, N. M., Browning, D. J., Elman, M. J., Ferris, F. L., Friedman, S. M., Melia, M., Pieramici, D. J., Sun, J. K., Beck, R. W., & Diabetic Retinopathy Clinical Research Network. (2015). Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. New England Journal of Medicine, 372(13), 1193-1203. https://doi.org/10.1056/NEJMoa1414264
- 6.Mitchell, P., Liew, G., Gopinath, B., & Wong, T. Y. (2018). Age-related macular degeneration. The Lancet, 392(10153), 1147-1159. https://doi.org/10.1016/S0140-6736(18)31550-2
- 7.Comparison of Age-related Macular Degeneration Treatments Trials Research Group. (2012). Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology, 119(7), 1388-1398. https://doi.org/10.1016/j.ophtha.2011.09.032
- 8.Wong, W. L., Su, X., Li, X., Cheung, C. M., Klein, R., Cheng, C. Y., & Wong, T. Y. (2014). Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet Global Health, 2(2), e106-e116. https://doi.org/10.1016/S2214-109X(13)70145-1
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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