Phase IV Trial Opens: Digital Cognitive Training Plus PCSK9 Inhibitor vs Standard Care in Intracranial Atherosclerotic Stenosis — Targeting Cognitive Decline
247 Health News Editorial
·31 May 2026
·3 min read
·clinical-trialsNew Phase IV trial combines digital cognitive training with intensive PCSK9 inhibitor therapy to prevent cognitive decline in intracranial atherosclerotic stenosis patients. The 420-participant study uses innovative 2×2 factorial design to evaluate both interventions.
Originally reported by ClinicalTrials.gov
References
- 1.Banerjee, G., Carare, R., Cordonnier, C., Greenberg, S. M., Schneider, J. A., Smith, E. E., ... & Werring, D. J. (2017). The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice. Journal of Neurology, Neurosurgery & Psychiatry, 88(11), 982-994. https://doi.org/10.1136/jnnp-2016-314697
- 2.Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., ... & Seshadri, S. (2011). Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 42(9), 2672-2713. https://doi.org/10.1161/STR.0b013e3182299496
- 3.Lampit, A., Hallock, H., & Valenzuela, M. (2014). Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLoS Medicine, 11(11), e1001756. https://doi.org/10.1371/journal.pmed.1001756
- 4.Peking Union Medical College Hospital. (2024). Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2×2 Randomized Controlled Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07605130
- 5.Sabayan, B., Westendorp, R. G., & van der Grond, J. (2012). Cognitive function, lipid profile, and stroke risk: the PROSPER study. Archives of Neurology, 69(11), 1482-1487. https://doi.org/10.1001/archneurol.2012.1803
- 6.Wang, Y., Zhao, X., Liu, L., Soo, Y. O., Pu, Y., Pan, Y., ... & Johnston, S. C. (2014). Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke, 45(3), 663-669. https://doi.org/10.1161/STROKEAHA.113.003508
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