Health Technology/clinical-trials

Phase IV Trial Opens: Digital Cognitive Training Plus PCSK9 Inhibitor vs Standard Care in Intracranial Atherosclerotic Stenosis — Targeting Cognitive Decline

247 Health News Editorial

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31 May 2026

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3 min read

·clinical-trials

New Phase IV trial combines digital cognitive training with intensive PCSK9 inhibitor therapy to prevent cognitive decline in intracranial atherosclerotic stenosis patients. The 420-participant study uses innovative 2×2 factorial design to evaluate both interventions.

Originally reported by ClinicalTrials.gov

References

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  4. 4.Peking Union Medical College Hospital. (2024). Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2×2 Randomized Controlled Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07605130
  5. 5.Sabayan, B., Westendorp, R. G., & van der Grond, J. (2012). Cognitive function, lipid profile, and stroke risk: the PROSPER study. Archives of Neurology, 69(11), 1482-1487. https://doi.org/10.1001/archneurol.2012.1803
  6. 6.Wang, Y., Zhao, X., Liu, L., Soo, Y. O., Pu, Y., Pan, Y., ... & Johnston, S. C. (2014). Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke, 45(3), 663-669. https://doi.org/10.1161/STROKEAHA.113.003508
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247 Health News Editorial

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