Phase IV Trial Opens: Bundled Intervention to Reduce Post-ED Opioid Overdose Deaths — What Emergency Physicians Need to Know

References

1. 1.Busch, S. H., Fiellin, D. A., Chawarski, M. C., Owens, P. H., Pantalon, M. V., Hawk, K., Bernstein, S. L., O'Connor, P. G., & D'Onofrio, G. (2017). Cost-effectiveness of emergency department-initiated treatment for opioid dependence. Addiction, 112(11), 2002-2010. https://doi.org/10.1111/add.13900
2. 2.D'Onofrio, G., O'Connor, P. G., Pantalon, M. V., Chawarski, M. C., Busch, S. H., Owens, P. H., Bernstein, S. L., & Fiellin, D. A. (2015). Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial. JAMA, 313(16), 1636-1644. https://doi.org/10.1001/jama.2015.3474
3. 3.Hawk, K. F., Vaca, F. E., & D'Onofrio, G. (2015). Reducing fatal opioid overdose: prevention, treatment and harm reduction strategies. Yale Journal of Biology and Medicine, 88(3), 235-245.
4. 4.Hedegaard, H., Miniño, A. M., & Warner, M. (2020). Drug overdose deaths in the United States, 1999-2018. NCHS Data Brief, 356, 1-8.
5. 5.Larochelle, M. R., Bernson, D., Land, T., Stopka, T. J., Wang, N., Xuan, Z., Bagley, S. M., Liebschutz, J. M., & Walley, A. Y. (2018). Medication for opioid use disorder after nonfatal overdose and association with mortality: a cohort study. Annals of Internal Medicine, 169(3), 137-145. https://doi.org/10.7326/M17-3107
6. 6.Roxburgh, A., Hall, W. D., Dobbins, T., Gisev, N., Burns, L., Pearson, S., & Degenhardt, L. (2017). Trends in heroin and pharmaceutical opioid overdose deaths in Australia. Drug and Alcohol Dependence, 179, 291-298. https://doi.org/10.1016/j.drugalcdep.2017.01.018
7. 7.Samuels, E. A., Clark, S. A., Wunsch, C., Jordison Keeler, L. A., Reddy, N., Vanjani, R., & Wightman, R. S. (2018). Innovation during COVID-19: improving addiction treatment access. Journal of Addiction Medicine, 14(4), e8-e9. https://doi.org/10.1097/ADM.0000000000000685
8. 8.University of Alabama at Birmingham. (2024). Implementation and Effectiveness of A Bundled Intervention to End Opioid Overdoses by Increasing Treatment Uptake Post Discharge. ClinicalTrials.gov. NCT07485335. https://clinicaltrials.gov/study/NCT07485335
9. 9.Weiner, S. G., Baker, O., Bernson, D., & Schuur, J. D. (2020). One-year mortality of patients after emergency department treatment for nonfatal opioid overdose. Annals of Emergency Medicine, 75(1), 13-17. https://doi.org/10.1016/j.annemergmed.2019.04.020