Phase IV Trial Opens: AI-Enhanced Digital Patient-Reported Outcomes Tool vs Standard Care in Type 2 Diabetes — What Clinicians Need to Know
247 Health News Editorial
·10 Apr 2026
·4 min read
·clinical-trialsThe iMatter2 trial investigates whether an AI-enhanced digital patient-reported outcomes tool can improve HbA1c levels in poorly controlled type 2 diabetes patients. This hybrid effectiveness-implementation study compares the novel mHealth intervention against usual primary care.
Originally reported by ClinicalTrials.gov
References
- 1.American Diabetes Association Professional Practice Committee. (2024). 6. Glycemic goals and hypoglycemia: Standards of Care in Diabetes—2024. Diabetes Care, 47(Supplement_1), S111-S125. https://doi.org/10.2337/dc24-S006
- 2.Australian Institute of Health and Welfare. (2023). Diabetes: Australian facts 2023 (AIHW-CVD-96). AIHW. https://www.aihw.gov.au/reports/diabetes/diabetes-australian-facts-2023
- 3.Basch, E., Deal, A. M., Dueck, A. C., Scher, H. I., Kris, M. G., Hudis, C., & Schrag, D. (2017). Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment. JAMA, 318(2), 197-198. https://doi.org/10.1001/jama.2017.7156
- 4.Curran, G. M., Bauer, M., Mittman, B., Pyne, J. M., & Stetler, C. (2012). Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care, 50(3), 217-226. https://doi.org/10.1097/MLR.0b013e3182408812
- 5.Greenwood, D. A., Gee, P. M., Fatkin, K. J., & Peeples, M. (2017). A systematic review of reviews evaluating technology-enabled diabetes self-management education and support. Journal of Diabetes Science and Technology, 11(5), 1015-1027. https://doi.org/10.1177/1932296816661506
- 6.NYU Langone Health. (2024). iMatter2: An Artificial Intelligence (AI)-Driven Approach to Supercharge a Novel Digital Patient-reported Outcomes Tool for Diabetes Management [Clinical trial registration NCT05884775]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05884775
- 7.Peek, M. E., Ferguson, M., Bergeron, N., Maltby, D., & Chin, M. H. (2014). Integrated community-healthcare diabetes interventions to reduce disparities. Current Diabetes Reports, 14(3), 467. https://doi.org/10.1007/s11892-013-0449-0
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247 Health News Editorial
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