Phase IV Real-World Study Reveals Nerivio Electrical Neuromodulation Reduces Rescue Medication Use in US Veterans with Migraine
247 Health News Editorial
·6 Apr 2026
·4 min read
·clinical-trialsA Phase IV real-world study of 466 US veterans demonstrates that the Nerivio electrical neuromodulation device significantly reduces rescue medication usage for acute migraine treatment. This landmark study provides crucial evidence for non-pharmacological migraine management in veteran populations.
Originally reported by ClinicalTrials.gov
References
- 1.Theranica Bio-Electronics. (2024). Treatment patterns, medication usage, effectiveness, and safety among US veterans using the remote electrical neuromodulation (REN) wearable device for migraine treatment. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07336420
- 2.Yarnitsky, D., Dodick, D. W., Grosberg, B. M., Burstein, R., Ironi, A., Harris, D., Lin, T., Silberstein, S. D., Lipton, R. B., Ashkenazi, A., Friedman, D., Mullin, C., Solstrand Dahlberg, L., Martelletti, P., Diener, H. C., Limmroth, V., Lanteri-Minet, M., Reuter, U., Kassel, E., ... Chou, D. E. (2019). Remote electrical neuromodulation (REN) relieves acute migraine: A randomized, double-blind, placebo-controlled, multicenter trial. Headache, 59(8), 1240-1252. https://doi.org/10.1111/head.13551
- 3.Reardon, M. A., Hutchinson, S., & Loder, E. (2021). Real-world evidence in migraine research: A systematic review. Cephalalgia, 41(9), 971-986. https://doi.org/10.1177/0333102421996355
- 4.Theeler, B. J., & Erickson, J. C. (2012). Mild head trauma and chronic headaches in returning US soldiers. Headache, 52(9), 1254-1261. https://doi.org/10.1111/j.1526-4610.2012.02115.x
- 5.Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of migraine: A disorder of sensory processing. Physiological Reviews, 97(2), 553-622. https://doi.org/10.1152/physrev.00034.2015
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service