Health Technology/clinical-trials

Phase IV Real-World Study Reveals Nerivio Electrical Neuromodulation Reduces Rescue Medication Use in US Veterans with Migraine

247 Health News Editorial

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6 Apr 2026

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4 min read

·clinical-trials

A Phase IV real-world study of 466 US veterans demonstrates that the Nerivio electrical neuromodulation device significantly reduces rescue medication usage for acute migraine treatment. This landmark study provides crucial evidence for non-pharmacological migraine management in veteran populations.

Originally reported by ClinicalTrials.gov

References

  1. 1.Theranica Bio-Electronics. (2024). Treatment patterns, medication usage, effectiveness, and safety among US veterans using the remote electrical neuromodulation (REN) wearable device for migraine treatment. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07336420
  2. 2.Yarnitsky, D., Dodick, D. W., Grosberg, B. M., Burstein, R., Ironi, A., Harris, D., Lin, T., Silberstein, S. D., Lipton, R. B., Ashkenazi, A., Friedman, D., Mullin, C., Solstrand Dahlberg, L., Martelletti, P., Diener, H. C., Limmroth, V., Lanteri-Minet, M., Reuter, U., Kassel, E., ... Chou, D. E. (2019). Remote electrical neuromodulation (REN) relieves acute migraine: A randomized, double-blind, placebo-controlled, multicenter trial. Headache, 59(8), 1240-1252. https://doi.org/10.1111/head.13551
  3. 3.Reardon, M. A., Hutchinson, S., & Loder, E. (2021). Real-world evidence in migraine research: A systematic review. Cephalalgia, 41(9), 971-986. https://doi.org/10.1177/0333102421996355
  4. 4.Theeler, B. J., & Erickson, J. C. (2012). Mild head trauma and chronic headaches in returning US soldiers. Headache, 52(9), 1254-1261. https://doi.org/10.1111/j.1526-4610.2012.02115.x
  5. 5.Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of migraine: A disorder of sensory processing. Physiological Reviews, 97(2), 553-622. https://doi.org/10.1152/physrev.00034.2015
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