Health Technology/clinical-trials

Phase IV Observational Study Opens: AI-Enhanced Cardiac CT for Cardiovascular Risk Stratification — 10,000-Patient International Registry

247 Health News Editorial

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17 May 2026

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3 min read

·clinical-trials

The CORONARY study is recruiting 10,000 patients to validate AI-enhanced cardiac CT for cardiovascular risk stratification. This observational study aims to improve prediction of future coronary events through advanced plaque characterisation and biomarker analysis.

Originally reported by ClinicalTrials.gov

References

  1. 1.University of Galway. (2024). Artificial Intelligence-assisted CT for Risk Stratification in COronary Artery Disease to PreveNt Future Coronary Events and Improve Outcomes. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07577609
  2. 2.Maurovich-Horvat, P., Ferencik, M., Voros, S., Merkely, B., & Hoffmann, U. (2014). Comprehensive plaque assessment by coronary CT angiography. Nature Reviews Cardiology, 11(7), 390-402. https://doi.org/10.1038/nrcardio.2014.60
  3. 3.Motwani, M., Dey, D., Berman, D. S., Germano, G., Achenbach, S., Al-Mallah, M. H., ... & Slomka, P. J. (2017). Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis. European Heart Journal, 38(7), 500-507. https://doi.org/10.1161/CIRCULATIONAHA.117.027797
  4. 4.Tsimikas, S. (2017). A test in context: lipoprotein(a): diagnosis, prognosis, controversies, and emerging therapies. Journal of the American College of Cardiology, 69(6), 692-711. https://doi.org/10.1016/j.jacc.2017.05.067
  5. 5.Tearney, G. J., Regar, E., Akasaka, T., Adriaenssens, T., Barlis, P., Bezerra, H. G., ... & International Working Group for Intravascular Optical Coherence Tomography. (2012). Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies. Journal of the American College of Cardiology, 59(12), 1058-1072. https://doi.org/10.1016/j.jacc.2012.06.035
  6. 6.Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., ... & ESC Scientific Document Group. (2020). 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal, 41(3), 407-477. https://doi.org/10.1093/eurheartj/ehz425
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