Health Technology/clinical-trials

Phase IV Observational Study: AI-Powered Diagnostic Tool for Oral Cancer Detection — 5,000-Patient Retrospective Analysis

247 Health News Editorial

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15 Apr 2026

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4 min read

·clinical-trials

French researchers launch ambitious 5,000-patient retrospective study to develop AI-powered diagnostic tool for oral cancer detection. The study aims to improve early identification of potentially malignant oral lesions using machine learning analysis of clinical photographs spanning five decades.

Originally reported by ClinicalTrials.gov

References

  1. 1.Assistance Publique - Hôpitaux de Paris. (2024). Artificial Intelligence for the Diagnosis of Oral Lesions. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07529769
  2. 2.Iocca, O., Sollecito, T. P., Alawi, F., Weinstein, G. S., Newman, J. G., De Virgilio, A., Di Maio, P., Spriano, G., Pardiñas López, S., & Shanti, R. M. (2020). Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype. Head & Neck, 42(3), 539-555. https://doi.org/10.1002/hed.26365
  3. 3.Johnson, D. E., Burtness, B., Leemans, C. R., Lui, V. W. Y., Bauman, J. E., & Grandis, J. R. (2020). Head and neck squamous cell carcinoma. Nature Reviews Disease Primers, 6(1), 92. https://doi.org/10.1038/s41572-020-00224-3
  4. 4.Lingen, M. W., Kalmar, J. R., Karrison, T., & Speight, P. M. (2008). Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncology, 44(1), 10-22. https://doi.org/10.1016/j.oraloncology.2008.06.001
  5. 5.Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249. https://doi.org/10.3322/caac.21660
  6. 6.Warnakulasuriya, S., Kujan, O., Aguirre-Urizar, J. M., Bagan, J. V., González-Moles, M. Á., Kerr, A. R., Lodi, G., Mello, F. W., Monteiro, L., Ogden, G. R., Sloan, P., & Johnson, N. W. (2021). Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification. Oral Diseases, 27(8), 1862-1880. https://doi.org/10.1111/odi.13704
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