Phase IV Implementation Trial: AI-Powered Decision Support for Acute Kidney Injury Detection in Emergency Departments — What Clinicians Need to Know
247 Health News Editorial
·22 Apr 2026
·4 min read
·clinical-trialsJohns Hopkins launches major implementation trial of AI-powered clinical decision support for acute kidney injury detection in emergency departments. The study will evaluate both clinical effectiveness and real-world implementation across 200,000 patients.
Originally reported by ClinicalTrials.gov
References
- 1.Johns Hopkins University. (2024). Transforming kidney care in the emergency department: A prospective effectiveness-implementation evaluation. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06840210
- 2.Hoste, E. A., Bagshaw, S. M., Bellomo, R., Cely, C. M., Colman, R., Cruz, D. N., Dale, A., Gammelager, H., Garland, A., Graetz, T. J., Granholm, A., Haase, M., Haase-Fielitz, A., Heegaard, K. D., Herrera-Gutiérrez, M. E., Holt, S. G., Lara-García, J., Laupland, K. B., Mårtensson, J., ... Kellum, J. A. (2015). Epidemiology of acute kidney injury in critically ill patients: The multinational AKI-EPI study. Intensive Care Medicine, 41(8), 1411-1423. https://doi.org/10.1007/s00134-015-3934-7
- 3.Curran, G. M., Bauer, M., Mittman, B., Pyne, J. M., & Stetler, C. (2012). Effectiveness-implementation hybrid designs: Combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care, 50(3), 217-226. https://doi.org/10.1097/MLR.0b013e3182408812
- 4.KDIGO AKI Work Group. (2012). KDIGO clinical practice guideline for acute kidney injury. Kidney International Supplements, 2(1), 1-138. https://doi.org/10.1038/kisup.2012.1
- 5.Proctor, E., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G., Bunger, A., Griffey, R., & Hensley, M. (2011). Outcomes for implementation research: Conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health, 38(2), 65-76. https://doi.org/10.1007/s10488-010-0319-7
- 6.Susantitaphong, P., Cruz, D. N., Cerda, J., Abulfaraj, M., Alqahtani, F., Koulouridis, I., & Jaber, B. L. (2013). World incidence of AKI: A meta-analysis. Clinical Journal of the American Society of Nephrology, 8(9), 1482-1493. https://doi.org/10.2215/CJN.00710113
- 7.Silver, S. A., & Chertow, G. M. (2017). The economic consequences of acute kidney injury. Nephron, 137(4), 297-301. https://doi.org/10.1159/000475607
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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