Health Technology/clinical-trials

Phase IV Implementation Trial: AI-Powered Decision Support for Acute Kidney Injury Detection in Emergency Departments — What Clinicians Need to Know

247 Health News Editorial

·

22 Apr 2026

·

4 min read

·clinical-trials

Johns Hopkins launches major implementation trial of AI-powered clinical decision support for acute kidney injury detection in emergency departments. The study will evaluate both clinical effectiveness and real-world implementation across 200,000 patients.

Originally reported by ClinicalTrials.gov

References

  1. 1.Johns Hopkins University. (2024). Transforming kidney care in the emergency department: A prospective effectiveness-implementation evaluation. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06840210
  2. 2.Hoste, E. A., Bagshaw, S. M., Bellomo, R., Cely, C. M., Colman, R., Cruz, D. N., Dale, A., Gammelager, H., Garland, A., Graetz, T. J., Granholm, A., Haase, M., Haase-Fielitz, A., Heegaard, K. D., Herrera-Gutiérrez, M. E., Holt, S. G., Lara-García, J., Laupland, K. B., Mårtensson, J., ... Kellum, J. A. (2015). Epidemiology of acute kidney injury in critically ill patients: The multinational AKI-EPI study. Intensive Care Medicine, 41(8), 1411-1423. https://doi.org/10.1007/s00134-015-3934-7
  3. 3.Curran, G. M., Bauer, M., Mittman, B., Pyne, J. M., & Stetler, C. (2012). Effectiveness-implementation hybrid designs: Combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care, 50(3), 217-226. https://doi.org/10.1097/MLR.0b013e3182408812
  4. 4.KDIGO AKI Work Group. (2012). KDIGO clinical practice guideline for acute kidney injury. Kidney International Supplements, 2(1), 1-138. https://doi.org/10.1038/kisup.2012.1
  5. 5.Proctor, E., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G., Bunger, A., Griffey, R., & Hensley, M. (2011). Outcomes for implementation research: Conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health, 38(2), 65-76. https://doi.org/10.1007/s10488-010-0319-7
  6. 6.Susantitaphong, P., Cruz, D. N., Cerda, J., Abulfaraj, M., Alqahtani, F., Koulouridis, I., & Jaber, B. L. (2013). World incidence of AKI: A meta-analysis. Clinical Journal of the American Society of Nephrology, 8(9), 1482-1493. https://doi.org/10.2215/CJN.00710113
  7. 7.Silver, S. A., & Chertow, G. M. (2017). The economic consequences of acute kidney injury. Nephron, 137(4), 297-301. https://doi.org/10.1159/000475607
Share:XLinkedIn
2

247 Health News Editorial

247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service