Health Technology/clinical-trials

Phase IV ELIOS Trial: Eye Movement Biomarkers to Track Ofatumumab Response in Multiple Sclerosis — What Clinicians Need to Know

247 Health News Editorial

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24 May 2026

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4 min read

·clinical-trials

The ELIOS trial evaluates novel eye movement biomarkers to track ofatumumab treatment response in Canadian RRMS patients. This phase IV study could revolutionise MS monitoring through objective, quantifiable neurological assessments.

Originally reported by ClinicalTrials.gov

References

  1. 1.Comabella, M., & Montalban, X. (2014). Body fluid biomarkers in multiple sclerosis. Lancet Neurology, 13(1), 113-126. https://doi.org/10.1016/S1474-4422(14)70233-3
  2. 2.Fielding, J., Kilpatrick, T., Millist, L., & White, O. (2009). Control of visually guided saccades in multiple sclerosis: disruption to higher-order processes. Neuropsychologia, 47(5), 1406-1415. https://doi.org/10.1016/j.neuropsychologia.2009.01.040
  3. 3.Frohman, E. M., Frohman, T. C., Zee, D. S., McColl, R., & Galetta, S. (2005). The neuro-ophthalmology of multiple sclerosis. Lancet Neurology, 4(2), 111-121. https://doi.org/10.1016/S1474-4422(05)70270-2
  4. 4.Hauser, S. L., Bar-Or, A., Cohen, J. A., Comi, G., Correale, J., Coyle, P. K., Cross, A. H., de Seze, J., Leppert, D., Montalban, X., Selmaj, K., Wiendl, H., Kerloeguen, C., Willi, R., Li, B., Kakarieka, A., Tomic, D., Goodyear, A., Pingili, R., ... Kappos, L. (2020). Ofatumumab versus teriflunomide in multiple sclerosis. New England Journal of Medicine, 383(6), 546-557. https://doi.org/10.1056/NEJMoa1917246
  5. 5.Kobelt, G., Thompson, A., Berg, J., Gannedahl, M., Eriksson, J., & MSCOI Study Group. (2017). New insights into the burden and costs of multiple sclerosis in Europe. Multiple Sclerosis Journal, 23(8), 1123-1136. https://doi.org/10.1177/1352458517694432
  6. 6.Novartis Pharmaceuticals. (2024). Exploratory Evaluation of Novel Investigational Eye Movement Biomarkers to Track Ofatumumab Treatment Response in Canadian Patients With Active Relapsing-Remitting Multiple Sclerosis (ELIOS). ClinicalTrials.gov. NCT06733922. https://clinicaltrials.gov/study/NCT06733922
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247 Health News Editorial

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