Phase IV Digital Platform Trial Opens: Remote GDMT Optimisation vs Usual Care in HFrEF — What Clinicians Need to Know
247 Health News Editorial
·30 Apr 2026
·3 min read
·clinical-trialsDigiCare-HFrEF trial investigates digital remote management platform for optimising guideline-directed medical therapy in heart failure patients with reduced ejection fraction. The multicentre randomised controlled trial compares algorithmic medication optimisation with usual care over three months.
Originally reported by ClinicalTrials.gov
References
- 1.Beijing Anzhen Hospital. (2024). Digital Remote Management for Care and Continuous Optimization Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction (DigiCare-HFrEF). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07352891
- 2.Greene, S. J., Butler, J., Albert, N. M., DeVore, A. D., Sharma, P. P., Duffy, C. I., Hill, C. L., McCague, K., Mi, X., Patterson, J. H., Spertus, J. A., Thomas, L., Williams, F. B., Hernandez, A. F., & Fonarow, G. C. (2018). Medical therapy for heart failure with reduced ejection fraction: the CHAMP-HF registry. Journal of the American College of Cardiology, 72(4), 351-366. https://doi.org/10.1016/j.jacc.2018.04.014
- 3.Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., Fang, J. C., Fedson, S. E., Fonarow, G. C., Hayek, S. S., Hernandez, A. F., Khazanie, P., Kittleson, M. M., Lee, C. S., Link, M. S., ... & Yancy, C. W. (2022). 2022 AHA/ACC/HFSA guideline for the management of heart failure. Circulation, 145(18), e895-e1032. https://doi.org/10.1161/CIR.0000000000001063
- 4.Keshvani, N., Patel, S., Gupta, A., Sharma, A., & Aronow, W. S. (2022). Digital health in heart failure: a systematic review of mobile health applications and their effectiveness. Current Problems in Cardiology, 47(3), 101045. https://doi.org/10.1016/j.cpcardiol.2021.101045
- 5.Komajda, M., Böhm, M., Borer, J. S., Ford, I., Tavazzi, L., Pannaux, M., Swedberg, K., & SHIFT Investigators. (2014). Incremental benefit of drug therapies for chronic heart failure over the last three decades: a systematic review and meta-analysis. European Journal of Heart Failure, 16(9), 1000-1007. https://doi.org/10.1002/ejhf.109
- 6.McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., ... & Kathrine Skibelund, A. (2021). 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, 42(36), 3599-3726. https://doi.org/10.1093/eurheartj/ehab368
- 7.Savarese, G., Becher, P. M., Lund, L. H., Seferovic, P., Rosano, G. M., & Coats, A. J. (2023). Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovascular Research, 119(6), 1218-1233. https://doi.org/10.1093/cvr/cvac013
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