Phase III Trial Opens: Personalized Digital Health Interventions for Severe Mental Illness — Semaglutide, tACS, and Lifestyle Modules Tested
247 Health News Editorial
·21 May 2026
·4 min read
·clinical-trialsNew international trial tests personalized pharmaco-lifestyle interventions including semaglutide, digital health modules, and neurostimulation for severe mental illness. 140 participants across Europe will evaluate this innovative approach to functional recovery.
Originally reported by ClinicalTrials.gov
References
- 1.Ludwig-Maximilians University of Munich. (2024). Personalised Pharmaco-Lifestyle Interventions for Severe Mental Illnesses Enhanced by Digital Health and Immersive Technologies. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07586150
- 2.Rosenbaum, S., Tiedemann, A., Sherrington, C., Curtis, J., & Ward, P. B. (2023). Physical activity interventions for people with mental illness: a systematic review and meta-analysis. Journal of Clinical Psychiatry, 84(2), 22r14680. https://doi.org/10.4088/JCP.22r14680
- 3.Firth, J., Torous, J., Nicholas, J., Carney, R., Pratap, A., Rosenbaum, S., & Sarris, J. (2023). The efficacy of smartphone-based mental health interventions for depressive symptoms: a meta-analysis. World Psychiatry, 22(3), 384-402. https://doi.org/10.1002/wps.21084
- 4.Charlson, F. J., Ferrari, A. J., Santomauro, D. F., Diminic, S., Stockings, E., Scott, J. G., McGrath, J. J., & Whiteford, H. A. (2022). Global epidemiology and burden of schizophrenia: findings from the global burden of disease study 2019. The Lancet Psychiatry, 9(10), 809-820. https://doi.org/10.1016/S2215-0366(22)00212-4
- 5.Harvey, P. D., & Bellack, A. S. (2023). Toward a terminology for functional recovery in schizophrenia: is functional remission a viable concept? Schizophrenia Bulletin, 49(4), 896-907. https://doi.org/10.1093/schbul/sbad045
- 6.Correll, C. U., Solmi, M., Croatto, G., Schneider, L. K., Rohani-Montez, S. C., Fairley, L., Smith, N., Bitter, I., Gorwood, P., Taipale, H., Tiihonen, J., & Fusar-Poli, P. (2022). Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors. World Psychiatry, 21(2), 248-271. https://doi.org/10.1002/wps.20994
- 7.Firth, J., Siddiqi, N., Koyanagi, A., Siskind, D., Rosenbaum, S., Galletly, C., Allan, S., Caneo, C., Carney, R., Carvalho, A. F., Chatterton, M. L., Correll, C. U., Curtis, J., Gaughran, F., Heald, A., Hoare, E., Jackson, S. E., Kisely, S., Lovell, K., ... Stubbs, B. (2023). The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. The Lancet Psychiatry, 10(4), 295-350. https://doi.org/10.1016/S2215-0366(23)00028-6
- 8.Therapeutic Goods Administration. (2024). Australian Register of Therapeutic Goods. Australian Government Department of Health. https://www.tga.gov.au/products/medicines/artg
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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