Health Technology/clinical-trials

Phase III Trial Opens: mHealth Text Intervention vs Standard Care for HIV Treatment Adherence in African Sex Workers — What Clinicians Need to Know

247 Health News Editorial

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19 May 2026

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4 min read

·clinical-trials

New trial tests whether personalised text messaging can improve HIV treatment adherence and viral suppression in African women sex workers. The 'Motivation Matters!' intervention delivers theory-based messages to support antiretroviral therapy initiation.

Originally reported by ClinicalTrials.gov

References

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  2. 2.Curran, G. M., Bauer, M., Mittman, B., Pyne, J. M., & Stetler, C. (2012). Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical Care, 50(3), 217-226. https://doi.org/10.1097/MLR.0b013e3182408812
  3. 3.Kanters, S., Park, J. J., Chan, K., Socias, M. E., Ford, N., Forrest, J. I., Druyts, E., Thorlund, K., Nachega, J. B., & Mills, E. J. (2017). Interventions to improve adherence to antiretroviral therapy: a systematic review and network meta-analysis. The Lancet HIV, 4(1), e31-e40. https://doi.org/10.1016/S2352-3018(16)30206-5
  4. 4.Kerrigan, D., Kennedy, C. E., Morgan-Thomas, R., Reza-Paul, S., Mwangi, P., Win, K. T., McFall, A., Fonner, V. A., & Butler, J. (2015). A community empowerment approach to the HIV response among sex workers: effectiveness, challenges, and considerations for implementation and scale-up. The Lancet, 385(9963), 172-185. https://doi.org/10.1016/S0140-6736(14)60973-9
  5. 5.Lester, R. T., Ritvo, P., Mills, E. J., Kariri, A., Karanja, S., Chung, M. H., Jack, W., Habyarimana, J., Sadatsafavi, M., Najafzadeh, M., Marra, C. A., Estambale, B., Ngugi, E., Ball, T. B., Thabane, L., Gelmon, L. J., Kimani, J., Ackers, M., & Plummer, F. A. (2010). Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. The Lancet, 376(9755), 1838-1845. https://doi.org/10.1016/S0140-6736(10)61997-6
  6. 6.Platt, L., Grenfell, P., Meiksin, R., Elmes, J., Sherman, S. G., Sanders, T., Mwangi, P., & Crago, A. L. (2018). Associations between sex work laws and sex workers' health: a systematic review and meta-analysis of quantitative and qualitative studies. PLoS Medicine, 15(12), e1002680. https://doi.org/10.1371/journal.pmed.1002680
  7. 7.Shannon, K., Strathdee, S. A., Goldenberg, S. M., Duff, P., Mwangi, P., Rusakova, M., Reza-Paul, S., Lau, J., Deering, K., Pickles, M. R., & Boily, M. C. (2015). Global epidemiology of HIV among female sex workers: influence of structural determinants. The Lancet, 385(9962), 55-71. https://doi.org/10.1016/S0140-6736(14)60931-4
  8. 8.UNAIDS. (2023). Global AIDS Update 2023: The path that ends AIDS. Joint United Nations Programme on HIV/AIDS. https://www.unaids.org/en/resources/documents/2023/global-aids-update-2023
  9. 9.University of Washington. (2024). Hybrid Type-1 Effectiveness-Implementation Trial of Motivation Matters! A Theory-Based mHealth Intervention to Support Early Antiretroviral Adherence in HIV+ African Women Who Engage in Sex Work. ClinicalTrials.gov. NCT06745050. https://clinicaltrials.gov/study/NCT06745050
  10. 10.World Health Organization. (2023). Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. World Health Organization. https://www.who.int/publications/i/item/9789240053779
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247 Health News Editorial

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