Phase III THRIVE-65 Trial: TeleHealth Exercise Intervention to Preserve Chemotherapy Dose Intensity in Older Breast Cancer Patients — What Oncologists Need to Know
247 Health News Editorial
·9 Apr 2026
·4 min read
·clinical-trialsThe THRIVE-65 trial investigates whether telehealth-delivered exercise intervention can help women aged 65+ maintain full chemotherapy dose intensity during breast cancer treatment. This innovative approach could transform supportive care for older cancer patients.
Originally reported by ClinicalTrials.gov
References
- 1.Bonadonna, G., Moliterni, A., Zambetti, M., Daidone, M. G., Pilotti, S., Gianni, L., & Valagussa, P. (2005). Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. JAMA, 294(4), 432-437. https://doi.org/10.1001/jama.294.4.432
- 2.Chirivella, I., Bermejo, B., Insa, A., Pérez-Fidalgo, A., Magro, A., Rosello, S., García-Garre, E., Martín, P., Bosch, A., Lluch, A. (2009). Optimal delivery of anthracycline-based chemotherapy in the adjuvant setting improves outcome of breast cancer patients. Breast Cancer Research and Treatment, 114(3), 479-484. https://doi.org/10.1007/s10549-008-0020-1
- 3.Dana-Farber Cancer Institute. (2024). TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients (THRIVE-65). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT05535192
- 4.Hurria, A., Mohile, S., Gajra, A., Klepin, H., Muss, H., Chapman, A., Feng, T., Smith, D., Sun, C. L., De Glas, N., Cohen, H. J., Katheria, V., Zavala, L., Levi, A., Akiba, C., Tew, W. P. (2016). Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. Journal of Clinical Oncology, 34(17), 2108-2115. https://doi.org/10.1200/JCO.2015.63.2043
- 5.Ligibel, J. A., Bohlke, K., May, A. M., Clinton, S. K., Demark-Wahnefried, W., Gilchrist, S. C., Irwin, M. L., Late, M., Mansfield, S., Marshall, T. F., Meyerhardt, J. A., Thomson, C. A. (2022). Exercise, diet, and weight management during cancer treatment: ASCO guideline. Journal of Clinical Oncology, 40(22), 2491-2507. https://doi.org/10.1200/JCO.22.00687
- 6.Muss, H. B., Polley, M. Y., Berry, D. A., Liu, H., Cirrincione, C. T., Theodoulou, M., Mauer, A. M., Kornblith, A. B., Partridge, A. H., Dressler, L. G., Cohen, H. J., Hudis, C. A., Winer, E. P. (2023). Adjuvant chemotherapy in older women with breast cancer: whom to treat and what regimen. Journal of Clinical Oncology, 41(1), 54-62. https://doi.org/10.1200/JCO.22.02639
- 7.Puts, M. T., Toubasi, S., Andrew, M. K., Ashe, M. C., Ploeg, J., Atkinson, E., Ayala, A. P., Roy, A., Rodríguez Monforte, M., Bergman, H., McGilton, K. (2014). Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review. PLoS One, 12(3), e0109718. https://doi.org/10.1371/journal.pone.0109718
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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