Health Technology/clinical-trials

Phase III Digital Therapeutic Trial: ACT on Vaping App for Young Adult E-Cigarette Cessation — What Clinicians Need to Know

247 Health News Editorial

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10 Apr 2026

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4 min read

·clinical-trials

A major clinical trial is testing a smartphone app using Acceptance and Commitment Therapy to help young adults quit vaping. The study will recruit 1,372 participants and use biochemical verification to measure success.

Originally reported by ClinicalTrials.gov

References

  1. 1.Benowitz, N. L., Bernert, J. T., Foulds, J., Hecht, S. S., Jacob, P., Jarvis, M. J., Joseph, A., Oncken, C., & Piper, M. E. (2020). Biochemical verification of tobacco use and abstinence: 2019 update. Nicotine & Tobacco Research, 22(7), 1086-1097. https://doi.org/10.1093/ntr/ntz132
  2. 2.Cullen, K. A., Gentzke, A. S., Sawdey, M. D., Chang, J. T., Anic, G. M., Wang, T. W., Creamer, M. R., Jamal, A., Ambrose, B. K., & King, B. A. (2019). E-cigarette use among youth in the United States, 2019. JAMA, 322(21), 2095-2103. https://doi.org/10.1001/jama.2019.18387
  3. 3.Fred Hutchinson Cancer Center. (2024). ACT on Vaping: Digital Therapeutic for Young Adult Vaping Cessation. ClinicalTrials.gov. NCT06909500. https://clinicaltrials.gov/study/NCT06909500
  4. 4.Graham, A. L., Jacobs, M. A., Amato, M. S., Cha, S., Bottcher, M. M., & Papandonatos, G. D. (2020). Digital interventions for tobacco cessation in young adults: A systematic review. Nicotine & Tobacco Research, 22(7), 1178-1189. https://doi.org/10.1093/ntr/ntaa102
  5. 5.Hayes, S. C., Strosahl, K. D., & Wilson, K. G. (2016). Acceptance and commitment therapy: The process and practice of mindful change (2nd ed.). Guilford Press.
  6. 6.Vogel, E. A., Ramo, D. E., Rubinstein, M. L., Delucchi, K. L., Darrow, S. M., Costello, C., Kapoor, S., & Prochaska, J. J. (2021). Effects of social media on young adults' e-cigarette use: A systematic review. Tobacco Control, 30(e1), e86-e93. https://doi.org/10.1136/tobaccocontrol-2020-056472
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