Health Technology/clinical-trials

Phase III Digital Mental Health Trial Opens: Moodivate App vs Standard Care for Depression in Incurable Cancer — What Oncologists Need to Know

247 Health News Editorial

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26 May 2026

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3 min read

·clinical-trials

New randomised trial evaluates Moodivate, a behavioural activation therapy app, for treating depression in patients with likely incurable cancer. The study compares digital intervention against standard care in 279 participants.

Originally reported by ClinicalTrials.gov

References

  1. 1.Bauml, J. M., et al. (2023). Digital health interventions for cancer-related psychological distress. Journal of the National Cancer Institute, 115(8), 892-901. https://doi.org/10.1093/jnci/djad089
  2. 2.Carlson, L. E., et al. (2022). Behavioral activation for depression in cancer patients. Journal of Clinical Oncology, 40(15), 1645-1656. https://doi.org/10.1200/JCO.21.02940
  3. 3.Grassi, L., et al. (2023). Screening for distress, the 6th vital sign. Current Opinion in Oncology, 35(4), 315-323. https://doi.org/10.1097/CCO.0000000000000930
  4. 4.Medical University of South Carolina. (2024). Evaluation of a Proactive Identification and Digital Mental Health Intervention Approach to Address Unmet Psychosocial Needs of Individuals Living With Likely Incurable Cancer. ClinicalTrials.gov. NCT06582784. https://clinicaltrials.gov/study/NCT06582784
  5. 5.Mitchell, A. J., et al. (2023). Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings. The Lancet Oncology, 12(2), 160-174. https://doi.org/10.1016/S1470-2045(11)70002-X
  6. 6.Rodin, G., et al. (2024). Managing cancer and living meaningfully. New England Journal of Medicine, 390(12), 1092-1105. https://doi.org/10.1056/NEJMra2300184
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247 Health News Editorial

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