Health Technology/clinical-trials

Phase III Digital Health Trial: My Wellbeing Guide App vs Standard Resources for Cancer-Related Depression — What Oncology Teams Need to Know

247 Health News Editorial

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23 Apr 2026

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4 min read

·clinical-trials

Large-scale trial of My Wellbeing Guide digital CBT intervention for cancer-related depression recruiting 6,516 patients. Results could transform psycho-oncology care delivery through scalable digital mental health solutions.

Originally reported by ClinicalTrials.gov

References

  1. 1.Australian Government Department of Health. (2023). Software as Medical Device: Guidance for industry. Therapeutic Goods Administration. https://www.tga.gov.au/resources/resource/guidance/software-medical-device-guidance-industry
  2. 2.Baumeister, H., Reichler, L., Munzinger, M., & Lin, J. (2014). The impact of guidance on Internet-based mental health interventions — A systematic review. Internet Interventions, 1(4), 205-215. https://doi.org/10.1016/j.invent.2014.08.003
  3. 3.Beatty, L., & Koczwara, B. (2010). An effectiveness study of a self-guided web-based CBT intervention for cancer-related distress. European Journal of Cancer Care, 19(4), 542-547. https://doi.org/10.1111/j.1365-2354.2009.01138.x
  4. 4.Caruso, R., GiuliaNanni, M., Riba, M. B., Sabato, S., & Grassi, L. (2017). Depressive spectrum disorders in cancer: diagnostic issues and intervention. A critical review. Current Psychiatry Reports, 19(6), 33. https://doi.org/10.1007/s11920-017-0826-2
  5. 5.Ford, I., & Norrie, J. (2016). Pragmatic trials. New England Journal of Medicine, 375(5), 454-463. https://doi.org/10.1056/NEJMra1510059
  6. 6.Jacobsen, P. B., & Wagner, L. I. (2012). A new quality standard: the integration of psychosocial care into routine cancer care. Journal of Clinical Oncology, 30(11), 1154-1159. https://doi.org/10.1200/JCO.2011.39.5046
  7. 7.Krebber, A. M. H., Buffart, L. M., Kleijn, G., Riepma, I. C., de Bree, R., Leemans, C. R., ... & Verdonck‐de Leeuw, I. M. (2014). Prevalence of depression in cancer patients: a meta‐analysis of diagnostic interviews and self‐report instruments. Psycho‐Oncology, 23(2), 121-130. https://doi.org/10.1002/pon.3409
  8. 8.Northwestern University. (2024). My Wellbeing Guide, Technology Facilitated Behavioral Intervention for Depression Among Diverse Patients in Ambulatory Oncology. ClinicalTrials.gov. NCT05369429. https://clinicaltrials.gov/study/NCT05369429
  9. 9.Pilkonis, P. A., Choi, S. W., Reise, S. P., Stover, A. M., Riley, W. T., & Cella, D. (2011). Item banks for measuring emotional distress from the Patient-Reported Outcomes Measurement Information System (PROMIS®). Assessment, 18(3), 263-283. https://doi.org/10.1177/1073191111411667
  10. 10.Schalet, B. D., Pilkonis, P. A., Yu, L., Dodds, N., Johnston, K. L., Yount, S., ... & Cella, D. (2016). Clinical validity of PROMIS Depression, Anxiety, and Anger across diverse clinical samples. Journal of Clinical Epidemiology, 73, 119-127. https://doi.org/10.1016/j.jclinepi.2015.08.036
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247 Health News Editorial

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