Phase III Cluster-RCT Opens: AI-Powered Nudge Strategy vs Standard Care for Colonoscopy Uptake in High-Risk Patients — What Clinicians Need to Know
247 Health News Editorial
·13 June 2026
·4 min read
·clinical-trialsNew cluster-randomised trial investigates AI-powered nudge strategies to improve colonoscopy uptake in high-risk patients aged 45-74. The AINC trial combines personalised AI chatbot education with behavioural nudges, addressing critical gaps in colorectal cancer screening compliance.
Originally reported by ClinicalTrials.gov
References
- 1.Davidson, K. W., Barry, M. J., Mangione, C. M., Cabana, M., Caughey, A. B., Davis, E. M., ... & US Preventive Services Task Force. (2021). Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA, 325(19), 1965-1977. https://doi.org/10.1001/jama.2021.6238
- 2.Dekker, E., Tanis, P. J., Vleugels, J. L. A., Kasi, P. M., & Wallace, M. B. (2019). Colorectal cancer. The Lancet, 394(10207), 1467-1480. https://doi.org/10.1016/S0140-6736(19)32319-0
- 3.Fudan University. (2024). AI-empowered Nudge to Improve Colonoscopy Uptake (AINC): A Pragmatic Cluster-Randomized Trial. ClinicalTrials.gov. NCT07612436. https://clinicaltrials.gov/study/NCT07612436
- 4.Hemming, K., Haines, T. P., Chilton, P. J., Girling, A. J., & Lilford, R. J. (2015). The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting. BMJ, 350, h391. https://doi.org/10.1136/bmj.h391
- 5.Senore, C., Basu, P., Anttila, A., Ponti, A., Tomatis, M., Vale, D. B., ... & Segnan, N. (2023). Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report. Gut, 72(7), 1390-1399. https://doi.org/10.1136/gutjnl-2022-328920
- 6.Thaler, R. H., & Sunstein, C. R. (2021). Nudge: The final edition. Yale University Press. https://doi.org/10.12987/9780300252705
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247 Health News Editorial
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