Health Technology/clinical-trials

Phase III Cluster-RCT Opens: AI-Powered Nudge Strategy vs Standard Care for Colonoscopy Uptake in High-Risk Patients — What Clinicians Need to Know

247 Health News Editorial

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13 June 2026

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4 min read

·clinical-trials

New cluster-randomised trial investigates AI-powered nudge strategies to improve colonoscopy uptake in high-risk patients aged 45-74. The AINC trial combines personalised AI chatbot education with behavioural nudges, addressing critical gaps in colorectal cancer screening compliance.

Originally reported by ClinicalTrials.gov

References

  1. 1.Davidson, K. W., Barry, M. J., Mangione, C. M., Cabana, M., Caughey, A. B., Davis, E. M., ... & US Preventive Services Task Force. (2021). Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA, 325(19), 1965-1977. https://doi.org/10.1001/jama.2021.6238
  2. 2.Dekker, E., Tanis, P. J., Vleugels, J. L. A., Kasi, P. M., & Wallace, M. B. (2019). Colorectal cancer. The Lancet, 394(10207), 1467-1480. https://doi.org/10.1016/S0140-6736(19)32319-0
  3. 3.Fudan University. (2024). AI-empowered Nudge to Improve Colonoscopy Uptake (AINC): A Pragmatic Cluster-Randomized Trial. ClinicalTrials.gov. NCT07612436. https://clinicaltrials.gov/study/NCT07612436
  4. 4.Hemming, K., Haines, T. P., Chilton, P. J., Girling, A. J., & Lilford, R. J. (2015). The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting. BMJ, 350, h391. https://doi.org/10.1136/bmj.h391
  5. 5.Senore, C., Basu, P., Anttila, A., Ponti, A., Tomatis, M., Vale, D. B., ... & Segnan, N. (2023). Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report. Gut, 72(7), 1390-1399. https://doi.org/10.1136/gutjnl-2022-328920
  6. 6.Thaler, R. H., & Sunstein, C. R. (2021). Nudge: The final edition. Yale University Press. https://doi.org/10.12987/9780300252705
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247 Health News Editorial

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