Phase II Trial Opens: Novel EEG Neurofeedback System vs Sham Training in PTSD — Machine Learning-Based Amygdala Targeting
247 Health News Editorial
·4 Apr 2026
·3 min read
·clinical-trialsA groundbreaking clinical trial is testing a novel EEG neurofeedback system that uses machine learning to target amygdala biomarkers in PTSD treatment. The 250-participant study compares active Prism training to sham neurofeedback, potentially revolutionising trauma therapy approaches.
Originally reported by ClinicalTrials.gov
References
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- 2.Australian Institute of Health and Welfare. (2021). Mental health services provided in emergency departments 2018–19. AIHW. https://www.aihw.gov.au/reports/mental-health-services/mental-health-services-in-australia
- 3.Flory, J. D., & Yehuda, R. (2015). Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations. Dialogues in Clinical Neuroscience, 17(2), 141-150. https://doi.org/10.31887/DCNS.2015.17.2/jflory
- 4.Foundation for Atlanta Veterans Education and Research. (2024). A Prospective Randomized Study of a Novel EEG Neurofeedback System for the Treatment of PTSD Using Machine Learning-Based Amygdala Biomarkers [Clinical trial registration NCT06770998]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06770998
- 5.Kearney, B. E., & Lanius, R. A. (2022). The brain-body disconnect: A somatic sensory basis for trauma-related disorders. Frontiers in Neuroscience, 16, 1015749. https://doi.org/10.3389/fnins.2022.1015749
- 6.Misaki, M., Barzilay, R., Zotev, V., Phillips, R., Cheng, S., & Bodurka, J. (2018). Real-time fMRI amygdala neurofeedback positive emotional training: proof of concept and feasibility. NeuroImage, 184, 547-559. https://doi.org/10.1016/j.neuroimage.2018.07.021
- 7.Phoenix Australia. (2020). Australian Guidelines for the Prevention and Treatment of Acute Stress Disorder, Posttraumatic Stress Disorder and Complex PTSD. https://www.phoenixaustralia.org/resources/ptsd-guidelines/
- 8.Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006). Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research—past, present, and future. Biological Psychiatry, 60(4), 376-382. https://doi.org/10.1016/j.biopsych.2006.06.004
- 9.Reiter, K., Andersen, S. B., & Carlsson, J. (2016). Neurofeedback treatment and posttraumatic stress disorder: effectiveness of neurofeedback on posttraumatic stress disorder and the optimal number of sessions. Journal of Nervous and Mental Disease, 204(1), 69-77. https://doi.org/10.1097/NMD.0000000000000551
- 10.Tolin, D. F., Gilliam, C., Wootton, B. M., Bowe, W., Bragdon, L. B., Davis, E., Hannan, S., Steinman, S. A., Worden, B., & Hallion, L. S. (2018). Psychometric properties of a structured diagnostic interview for DSM-5 anxiety, mood, and obsessive-compulsive and related disorders. Assessment, 25(1), 3-13. https://doi.org/10.1177/1073191116638410
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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