Health Technology/clinical-trials

Phase II Trial Opens: Mobile Health-Supported HIIT Rehabilitation vs Standard Care for Post-COVID Critical Illness Recovery — What Clinicians Need to Know

247 Health News Editorial

·

15 June 2026

·

4 min read

·clinical-trials

Duke University trial tests mobile health-supported high-intensity interval training for COVID-19 ICU survivors. Primary endpoint: 6-minute walk distance improvement over 12 weeks.

Originally reported by ClinicalTrials.gov

References

  1. 1.Connolly, B., Salisbury, L., O'Neill, B., Geneen, L. J., Douiri, A., Grocott, M. P., Hart, N., Walsh, T. S., & Blackwood, B. (2015). Exercise rehabilitation following intensive care unit discharge for recovery from critical illness. Cochrane Database of Systematic Reviews, (6), CD008632. https://doi.org/10.1002/14651858.CD008632.pub2
  2. 2.Crapo, R. O., Casaburi, R., Coates, A. L., Enright, P. L., MacIntyre, N. R., McKay, R. T., Johnson, D., Wanger, J. S., Zeballos, R. J., Bittner, V., & Mottram, C. (2002). ATS statement: guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine, 166(1), 111-117. https://doi.org/10.1164/ajrccm.166.1.at1102
  3. 3.Cutler, D. M. (2022). The costs of long COVID. JAMA Health Forum, 3(4), e220811. https://doi.org/10.1001/jamahealthforum.2022.0811
  4. 4.Denehy, L., Skinner, E. H., Edbrooke, L., Haines, K., Warrillow, S., Hawthorne, G., Gough, K., Hoorn, S. V., Morris, M. E., & Berney, S. (2013). Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Critical Care, 17(4), R156. https://doi.org/10.1186/cc12835
  5. 5.Duke University. (2024). REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19. ClinicalTrials.gov. NCT05218083. https://clinicaltrials.gov/study/NCT05218083
  6. 6.Herridge, M. S., Moss, M., Hough, C. L., Hopkins, R. O., Rice, T. W., Bienvenu, O. J., Azoulay, E., Biehl, M., Ely, E. W., Harhay, M. O., Jackson, J. C., Latronico, N., Needham, D. M., Oakley, R., Tansey, C. M., Truong, A. D., Turgeon, A. F., Iwashyna, T. J., & Spragg, R. G. (2016). Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Medicine, 42(5), 725-738. https://doi.org/10.1007/s00134-016-4321-8
  7. 7.Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., Kang, L., Guo, L., Liu, M., Zhou, X., Luo, J., Huang, Z., Tu, S., Zhao, Y., Chen, L., Xu, D., Li, Y., Li, C., Peng, L., Li, Y., Xie, W., Cui, D., Shang, L., Fan, G., Xu, J., Wang, G., Wang, Y., Zhong, J., Wang, C., Wang, J., Zhang, D., & Cao, B. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet, 397(10270), 220-232. https://doi.org/10.1016/S0140-6736(20)32656-8
  8. 8.Needham, D. M., Davidson, J., Cohen, H., Hopkins, R. O., Weinert, C., Wunsch, H., Zawistowski, C., Bemis-Dougherty, A., Berney, S. C., Bienvenu, O. J., Brady, S. L., Brodsky, M. B., Denehy, L., Elliott, D., Flatley, C., Harabin, A. L., Jones, C., Louis, D., Meltzer, W., Muldoon, S. R., Palmer, J. B., Perme, C., Robinson, M., Schmidt, D. M., Scruth, E., Spill, G. R., Storey, C. P., Render, M., Votto, J., & Harvey, M. A. (2012). Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Critical Care Medicine, 40(2), 502-509. https://doi.org/10.1097/CCM.0b013e318232da75
Share:XLinkedIn
2

247 Health News Editorial

247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service