Phase II Trial Opens: Mobile Health-Supported HIIT Rehabilitation vs Standard Care for Post-COVID Critical Illness Recovery — What Clinicians Need to Know
247 Health News Editorial
·15 June 2026
·4 min read
·clinical-trialsDuke University trial tests mobile health-supported high-intensity interval training for COVID-19 ICU survivors. Primary endpoint: 6-minute walk distance improvement over 12 weeks.
Originally reported by ClinicalTrials.gov
References
- 1.Connolly, B., Salisbury, L., O'Neill, B., Geneen, L. J., Douiri, A., Grocott, M. P., Hart, N., Walsh, T. S., & Blackwood, B. (2015). Exercise rehabilitation following intensive care unit discharge for recovery from critical illness. Cochrane Database of Systematic Reviews, (6), CD008632. https://doi.org/10.1002/14651858.CD008632.pub2
- 2.Crapo, R. O., Casaburi, R., Coates, A. L., Enright, P. L., MacIntyre, N. R., McKay, R. T., Johnson, D., Wanger, J. S., Zeballos, R. J., Bittner, V., & Mottram, C. (2002). ATS statement: guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine, 166(1), 111-117. https://doi.org/10.1164/ajrccm.166.1.at1102
- 3.Cutler, D. M. (2022). The costs of long COVID. JAMA Health Forum, 3(4), e220811. https://doi.org/10.1001/jamahealthforum.2022.0811
- 4.Denehy, L., Skinner, E. H., Edbrooke, L., Haines, K., Warrillow, S., Hawthorne, G., Gough, K., Hoorn, S. V., Morris, M. E., & Berney, S. (2013). Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Critical Care, 17(4), R156. https://doi.org/10.1186/cc12835
- 5.Duke University. (2024). REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19. ClinicalTrials.gov. NCT05218083. https://clinicaltrials.gov/study/NCT05218083
- 6.Herridge, M. S., Moss, M., Hough, C. L., Hopkins, R. O., Rice, T. W., Bienvenu, O. J., Azoulay, E., Biehl, M., Ely, E. W., Harhay, M. O., Jackson, J. C., Latronico, N., Needham, D. M., Oakley, R., Tansey, C. M., Truong, A. D., Turgeon, A. F., Iwashyna, T. J., & Spragg, R. G. (2016). Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Medicine, 42(5), 725-738. https://doi.org/10.1007/s00134-016-4321-8
- 7.Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., Kang, L., Guo, L., Liu, M., Zhou, X., Luo, J., Huang, Z., Tu, S., Zhao, Y., Chen, L., Xu, D., Li, Y., Li, C., Peng, L., Li, Y., Xie, W., Cui, D., Shang, L., Fan, G., Xu, J., Wang, G., Wang, Y., Zhong, J., Wang, C., Wang, J., Zhang, D., & Cao, B. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet, 397(10270), 220-232. https://doi.org/10.1016/S0140-6736(20)32656-8
- 8.Needham, D. M., Davidson, J., Cohen, H., Hopkins, R. O., Weinert, C., Wunsch, H., Zawistowski, C., Bemis-Dougherty, A., Berney, S. C., Bienvenu, O. J., Brady, S. L., Brodsky, M. B., Denehy, L., Elliott, D., Flatley, C., Harabin, A. L., Jones, C., Louis, D., Meltzer, W., Muldoon, S. R., Palmer, J. B., Perme, C., Robinson, M., Schmidt, D. M., Scruth, E., Spill, G. R., Storey, C. P., Render, M., Votto, J., & Harvey, M. A. (2012). Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Critical Care Medicine, 40(2), 502-509. https://doi.org/10.1097/CCM.0b013e318232da75
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247 Health News Editorial
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