Phase II Trial Opens: Metformin Plus Remote Cognitive Monitoring vs Standard Care in Brain Tumour Patients Post-Cranial Radiation — What Clinicians Need to Know
247 Health News Editorial
·18 July 2026
·5 min read
·clinical-trialsA Mayo Clinic Phase II trial is now recruiting to evaluate whether metformin can prevent radiation-induced cognitive decline in brain tumour patients, while simultaneously testing the feasibility of fully remote neurocognitive monitoring via wearable devices and the Mayo Test Drive digital platform. With no approved pharmacological strategies currently available to protect cognition after cranial radiation, this trial addresses one of neuro-oncology's most pressing unmet clinical needs.
Originally reported by ClinicalTrials.gov
References
- 1.Mayo Clinic. (2024). Neuro-Oncology Anywhere: Deploying Mayo Clinic's Remote Cognitive Assessment Battery and Wearable Device Monitoring Platform While Assessing the Impact of Metformin on Cognition and Quality of Life in Patients With History of Cranial Radiation (NCT06377696). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06377696
- 2.Gondi, V., Pugh, S. L., Tome, W. A., Caine, C., Corn, B., Kanner, A., Rowley, H., Kundapur, V., DeNittis, A., Greenspoon, J. N., Konski, A. A., Bauman, G. S., Shah, S., Shi, W., Wendland, M., Kachnic, L., & Mehta, M. P. (2014). Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial. Journal of Clinical Oncology, 32(34), 3810–3816. https://doi.org/10.1200/JCO.2014.57.2909
- 3.Łabuzek, K., Suchy, D., Gabryel, B., Bielecka, A., Liber, S., & Okopień, B. (2010). Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide. Pharmacological Reports, 62(5), 956–965. https://doi.org/10.1016/S1734-1140(10)70300-7
- 4.Gehring, K., Aaronson, N. K., Taphoorn, M. J. B., & Sitskoorn, M. M. (2011). Interventions for cognitive deficits in patients with a brain tumor: An update. Expert Review of Anticancer Therapy, 11(11), 1779–1795. https://doi.org/10.1586/era.11.82
- 5.Wefel, J. S., Kesler, S. R., Noll, K. R., & Schagen, S. B. (2015). Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA: A Cancer Journal for Clinicians, 65(2), 123–138. https://doi.org/10.3322/caac.21258
- 6.Brown, P. D., Gondi, V., Pugh, S., Tome, W. A., Wefel, J. S., Armstrong, T. S., Bovi, J. A., Robinson, C., Konski, A., Khuntia, D., Grosshans, D., Benzinger, T. L. S., Bruner, D., Gilbert, M. R., Roberge, D., Kundapur, V., Devisetty, K., Shah, S., Usuki, K., … Mehta, M. P. (2020). Hippocampal avoidance during whole-brain radiotherapy plus memantine for 1–3 brain metastases: Phase III trial NRG Oncology CC001. Journal of Clinical Oncology, 38(10), 1019–1029. https://doi.org/10.1200/JCO.19.02767
2
247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
Related Articles
clinical-trials
Digital Health Platform vs Case Manager Support in Hypertension Management: Taiwan's 1,726-Participant Trial Signals a Shift in Blood Pressure Care Delivery
3 Aug 2026
clinical-trials
Phase II Trial: AI-Powered Wysa Chatbot vs Unmet Need — Digital Eating Disorder Prevention in At-Risk Adolescents
3 Aug 2026
clinical-trials
Pilot Trial Targets the Inpatient-to-Outpatient Gap: Digital Smoking Cessation Intervention for Persons With Serious Mental Illness — Key Findings for Clinicians
3 Aug 2026
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service