Health Technology/clinical-trials

Phase II Trial Opens: Guanfacine Extended Release vs Placebo in Alcohol Use Disorder — Telehealth-Based Approach Shows Promise

247 Health News Editorial

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19 May 2026

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3 min read

·clinical-trials

A new phase II trial is testing guanfacine extended release against placebo for alcohol use disorder using telehealth delivery. The study targets stress-related drinking patterns and could expand treatment options for AUD.

Originally reported by ClinicalTrials.gov

References

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  2. 2.Australian Institute of Health and Welfare. (2023). Alcohol, tobacco & other drugs in Australia. AIHW. https://www.aihw.gov.au/reports/alcohol/alcohol-tobacco-other-drugs-australia
  3. 3.Fox, H. C., Bergquist, K. L., Hong, K. I., & Sinha, R. (2007). Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals. Alcoholism: Clinical and Experimental Research, 31(3), 395-403. https://doi.org/10.1111/j.1530-0277.2007.00395.x
  4. 4.Indiana University. (2024). Guanfacine for Alcohol Use Disorder (AUD): a Telehealth Approach. ClinicalTrials.gov. NCT06629259. https://clinicaltrials.gov/study/NCT06629259
  5. 5.Jonas, D. E., Amick, H. R., Feltner, C., et al. (2014). Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis. JAMA, 311(18), 1889-1900. https://doi.org/10.1001/jama.2014.3628
  6. 6.Koob, G. F., & Volkow, N. D. (2016). Neurobiology of addiction: a neurocircuitry analysis. The Lancet Psychiatry, 3(8), 760-773. https://doi.org/10.1016/S2215-0366(16)00104-8
  7. 7.Lubman, D. I., Manning, V., Best, D., et al. (2014). A study of patient pathways in alcohol and other drug treatment. Medical Journal of Australia, 200(4), 214-218. https://doi.org/10.5694/mja13.11718
  8. 8.Riper, H., Hoogendoorn, A., Cuijpers, P., et al. (2018). Effectiveness and treatment moderators of internet interventions for adult problem drinking: an individual patient data meta-analysis of 19 randomised controlled trials. PLoS Medicine, 15(12), e1002714. https://doi.org/10.1371/journal.pmed.1002714
  9. 9.Simpson, T. L., Saxon, A. J., Meredith, C. W., et al. (2009). A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcoholism: Clinical and Experimental Research, 33(2), 269-275. https://doi.org/10.1111/j.1530-0277.2008.00807.x
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247 Health News Editorial

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