Health Technology/clinical-trials

Phase II Trial Evaluates AI-Assisted Contouring for Prostate HDR Brachytherapy — Precision Radiation Planning Under Investigation

247 Health News Editorial

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14 June 2026

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4 min read

·clinical-trials

A Phase II trial at Brigham and Women's Hospital is evaluating AI-assisted prostate contouring for HDR brachytherapy planning. The study compares AI-generated contours with traditional manual methods to improve treatment precision and workflow efficiency.

Originally reported by ClinicalTrials.gov

References

  1. 1.ClinicalTrials.gov. (2024). A Phase II Randomized Study of the Use of Artificial Intelligence Generated Contours in Ultrasound-based Prostate HDR Brachytherapy. https://clinicaltrials.gov/study/NCT06964412
  2. 2.Hoskin, P., Rojas, A., Bownes, P., & Bryant, L. (2012). Randomised trial of external beam radiotherapy alone or combined with high-dose-rate brachytherapy boost for localised prostate cancer. Radiotherapy and Oncology, 103(2), 217-222. https://doi.org/10.1016/j.radonc.2012.03.011
  3. 3.Kirisits, C., Rivard, M. J., Baltas, D., Ballester, F., De Brabandere, M., van der Laarse, R., ... & Venselaar, J. (2014). Review of clinical brachytherapy uncertainties: analysis guidelines of GEC-ESTRO and the AAPM. Radiotherapy and Oncology, 110(1), 199-212. https://doi.org/10.1016/j.radonc.2014.02.023
  4. 4.Prada, P. J., Gonzalez, H., Menendez, C., Llaneza, A., Fernandez, J., Santamarta, E., & Ricarte, P. (2012). Transperineal injection of hyaluronic acid in the anterior perirectal fat to decrease rectal toxicity from radiation delivered with low-dose-rate brachytherapy for prostate cancer patients. Brachytherapy, 11(3), 218-223. https://doi.org/10.1016/j.brachy.2011.10.002
  5. 5.Jameson, M. G., Holloway, L. C., Vial, P. J., Vinod, S. K., & Metcalfe, P. E. (2010). A review of methods of analysis in contouring studies for radiation oncology. Journal of Medical Imaging and Radiation Oncology, 54(5), 401-410. https://doi.org/10.1111/j.1754-9485.2010.02192.x
  6. 6.Cardenas, C. E., Yang, J., Anderson, B. M., Court, L. E., & Brock, K. B. (2019). Advances in auto-segmentation. Seminars in Radiation Oncology, 29(3), 185-197. https://doi.org/10.1016/j.semradonc.2019.02.001
  7. 7.Morton, G., Loblaw, A., Chung, H., Tsang, G., Sankreacha, R., Deabreu, A., ... & Cheung, P. (2017). Health-related quality of life after single-fraction high-dose-rate brachytherapy and hypofractionated external beam radiotherapy for prostate cancer. International Journal of Radiation Oncology, Biology, Physics, 98(3), 570-578. https://doi.org/10.1016/j.ijrobp.2017.04.015
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