Phase II Digital Health Trial: Adaptive Clinical Decision Support System for Emergency Department Opioid Use Disorder Management
247 Health News Editorial
·8 June 2026
·3 min read
·clinical-trialsYale University launches Phase II trial of EMBED clinical decision support system to improve emergency department management of opioid use disorder. The adaptive design study will refine digital alerts prompting addiction counselor consultations for eligible patients.
Originally reported by ClinicalTrials.gov
References
- 1.Yale University. (2024). Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07602218
- 2.Hawk, K., Vaca, F., & D'Onofrio, G. (2015). Reducing fatal opioid overdose: prevention, treatment and harm reduction strategies. Yale Journal of Biology and Medicine, 88(3), 235-245.
- 3.Bauer, M. S., Damschroder, L., Hagedorn, H., Smith, J., & Kilbourne, A. M. (2015). An introduction to implementation science for the non-specialist. BMC Psychology, 3(1), 32. https://doi.org/10.1186/s40359-015-0089-9
- 4.American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Publishing.
- 5.D'Onofrio, G., O'Connor, P. G., Pantalon, M. V., Chawarski, M. C., Busch, S. H., Owens, P. H., ... & Fiellin, D. A. (2015). Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial. JAMA, 313(16), 1636-1644. https://doi.org/10.1001/jama.2015.3474
- 6.Weiner, S. G., Baker, O., Bernson, D., & Schuur, J. D. (2020). One-year mortality of patients after emergency department treatment for nonfatal opioid overdose. Annals of Emergency Medicine, 75(1), 13-17. https://doi.org/10.1016/j.annemergmed.2019.04.020
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247 Health News Editorial
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