Health technology: Pfizer's Monthly Obesity Drug Shows Sustained Weight Loss in Phase 2 Trial

Pfizer's Monthly Obesity Drug Shows Sustained Weight Loss in Phase 2 Trial

247 Health News Editorial

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7 June 2026

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3 min read

·healthtech

Pfizer's berobenatide shows sustained 12.1% weight loss with monthly dosing in VESPER-3 trial. Monthly injection schedule could improve patient adherence compared to weekly obesity medications.

Originally reported by STAT News

References

  1. 1.Chen, E. (2026, June 6). Detailed data show Pfizer's monthly obesity drug continues to show potential. STAT News. https://www.statnews.com/2026/06/06/pfizer-obesity-drug-berobenatide-metsera-results/
  2. 2.Pfizer Inc. (2026). VESPER-3 trial results for berobenatide. American Diabetes Association Scientific Sessions. https://professional.diabetes.org/scientific-sessions
  3. 3.Kushner, R. F., & Ryan, D. H. (2024). Assessment and lifestyle management of patients with obesity. JAMA, 331(4), 321-331. https://doi.org/10.1001/jama.2024.0064
  4. 4.Wilding, J. P., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., ... & Kushner, R. F. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989-1002. https://doi.org/10.1056/NEJMoa2032183
  5. 5.Igel, L. I., Kumar, R. B., Saunders, K. H., & Aronne, L. J. (2023). Practical use of pharmacotherapy for obesity. Gastroenterology, 165(1), 31-43. https://doi.org/10.1053/j.gastro.2023.03.214
  6. 6.Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & Garvey, W. T. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216. https://doi.org/10.1056/NEJMoa2206038
  7. 7.Rubino, D., Abramo, A., Aronne, L. J., Batterham, R. L., Buscemi, S., Dicker, D., ... & Wadden, T. A. (2021). Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance. JAMA, 325(14), 1414-1425. https://doi.org/10.1001/jama.2021.3224
  8. 8.Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., ... & Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines. (2024). American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocrine Practice, 30(3), 138-169. https://doi.org/10.1016/j.eprac.2024.02.001
  9. 9.Ryan, D. H., & Kahan, S. (2023). Guideline recommendations for obesity management. Medical Clinics of North America, 107(6), 1115-1129. https://doi.org/10.1016/j.mcna.2023.06.005
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247 Health News Editorial

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