Health Technology/clinical-trials

OPAL Trial Opens: Online Prehabilitation vs Standard Care for Pre-Transplant Liver Patients — Targeting Frailty Reduction

247 Health News Editorial

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9 Apr 2026

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4 min read

·clinical-trials

The OPAL trial tests whether 12-week online prehabilitation can reduce frailty and improve outcomes in liver transplant candidates. This Canadian multicentre RCT addresses a critical gap in pre-transplant care through accessible virtual delivery.

Originally reported by ClinicalTrials.gov

References

  1. 1.Bohannon, R. W. (2006). Reference values for the five-repetition sit-to-stand test: a descriptive meta-analysis of data from elders. Perceptual and Motor Skills, 103(1), 215-222. https://doi.org/10.2466/pms.103.1.215-222
  2. 2.Bernal, W., Martin-Mateos, R., Lisman, T., Forrest, E. H., Gines, P., Wendon, J., & Moreau, R. (2022). Aerobic capacity during cardiopulmonary exercise testing and survival with and without liver transplantation for patients with chronic liver disease. Liver Transplantation, 28(10), 1627-1639. https://doi.org/10.1002/lt.26509
  3. 3.Carli, F., Bousquet-Dion, G., Awasthi, R., Elsherbini, N., Liberman, S., Boutros, M., & Stein, B. (2020). Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer. JAMA Surgery, 155(3), 233-242. https://doi.org/10.1001/jamasurg.2020.0178
  4. 4.Lai, J. C., Covinsky, K. E., Dodge, J. L., Boscardin, W. J., Segev, D. L., Roberts, J. P., & Feng, S. (2014). Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology, 60(2), 564-574. https://doi.org/10.1002/hep.27014
  5. 5.Sinclair, M., Poltavskiy, E., Dodge, J. L., & Lai, J. C. (2019). Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist. World Journal of Gastroenterology, 25(41), 6178-6186. https://doi.org/10.3748/wjg.v25.i41.6178
  6. 6.University of Alberta. (2023). OPAL: Online Prehabilitation for Patients Awaiting Liver Transplantation - a Multicenter Randomized Controlled Trial to Reduce Physical Frailty and Improve Health Outcomes. ClinicalTrials.gov NCT05899231. https://clinicaltrials.gov/study/NCT05899231
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247 Health News Editorial

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