Observational Study Launches: Gastrointestinal Blood Flow Predicts Enteral Nutrition Intolerance in ICU Patients — What Intensivists Need to Know
247 Health News Editorial
·11 Apr 2026
·4 min read
·clinical-trialsNew observational study investigates whether gastrointestinal blood flow measured by point-of-care ultrasound can predict enteral nutrition intolerance in critically ill patients. The 500-patient study aims to develop predictive models to improve nutrition delivery in ICU settings.
Originally reported by ClinicalTrials.gov
References
- 1.Chapple, L. S., Deane, A. M., Heyland, D. K., Lange, K., Kranz, A. J., Williams, L. T., & Chapman, M. J. (2020). Energy and protein deficits throughout hospitalization in patients admitted with a traumatic brain injury. Clinical Nutrition, 39(4), 1209-1218. https://doi.org/10.1016/j.clnu.2019.02.030
- 2.Collins, G. S., Reitsma, J. B., Altman, D. G., & Moons, K. G. (2015). Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ, 350, g7594. https://doi.org/10.1136/bmj.g7594
- 3.Compher, C., Chittams, J., Sammarco, T., Nicolo, M., & Heyland, D. K. (2017). Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter, multinational observational study. Critical Care Medicine, 45(2), 156-163. https://doi.org/10.1097/CCM.0000000000002083
- 4.Heyland, D. K., Cahill, N. E., Dhaliwal, R., Sun, X., Day, A. G., & McClave, S. A. (2010). Enhanced protein-energy provision via the enteral route in critically ill patients: a single center feasibility trial of the PEP uP protocol. Critical Care, 14(2), R78. https://doi.org/10.1186/cc8991
- 5.Mentec, H., Dupont, H., Bocchetti, M., Cani, P., Ponche, F., & Bleichner, G. (2001). Upper digestive intolerance during enteral nutrition in critically ill patients: frequency, risk factors, and complications. Critical Care Medicine, 29(10), 1955-1961. https://doi.org/10.1097/00003246-200101000-00018
- 6.Piton, G., Belon, F., Cypriani, B., Regnard, J., Puyraveau, M., Manzon, C., ... & Capellier, G. (2013). Enterocyte damage in critically ill patients is associated with shock condition and 28-day mortality. Critical Care Medicine, 41(9), 2169-2176. https://doi.org/10.1097/CCM.0b013e318275893c
- 7.Reintam Blaser, A., Starkopf, J., Alhazzani, W., Berger, M. M., Casaer, M. P., Deane, A. M., ... & Preiser, J. C. (2017). Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Medicine, 43(3), 380-398. https://doi.org/10.1007/s00134-016-4665-0
- 8.Ruijin Hospital. (2024). Study on the Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients. ClinicalTrials.gov. NCT07521111. https://clinicaltrials.gov/study/NCT07521111
- 9.Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., ... & Bischoff, S. C. (2019). ESPEN guideline on clinical nutrition in the intensive care unit. Clinical Nutrition, 38(1), 48-79. https://doi.org/10.1016/j.clnu.2018.08.037
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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